Gene: PPP6R1
Official Full Name: protein phosphatase 6 regulatory subunit 1provided by HGNC
Gene Summary: Protein phosphatase regulatory subunits, such as SAPS1, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS1 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO06047 | PPP6R1 Knockout cell line (HeLa) | Human | PPP6R1 | 1:3~1:6 | Negative | Online Inquiry |
KO06048 | PPP6R1 Knockout cell line (HCT 116) | Human | PPP6R1 | 1:2~1:4 | Negative | Online Inquiry |
KO06049 | PPP6R1 Knockout cell line (HEK293) | Human | PPP6R1 | 1:3~1:6 | Negative | Online Inquiry |
KO06050 | PPP6R1 Knockout cell line (A549) | Human | PPP6R1 | 1:3~1:4 | Negative | Online Inquiry |
PPP6R1 Gene Knockout Cell Lines are specialized cellular models engineered to disrupt the expression of the PPP6R1 gene, which encodes for a regulatory subunit of protein phosphatase 6. These cell lines are invaluable tools in molecular biology and genetics, enabling researchers to study the specific roles of PPP6R1 in cellular processes such as signal transduction, cell cycle regulation, and tumorigenesis. By selectively knocking out the PPP6R1 gene, scientists can observe the resulting phenotypic changes and elucidate the pathways influenced by this protein, thus providing vital insights into developmental biology and disease mechanisms.
The functionality of these knockout cell lines lies in their ability to mimic the loss-of-function mutations commonly observed in various cancers and other pathologies. This mechanism allows for the examination of the downstream effects and compensatory pathways activated in the absence of PPP6R1, facilitating a deeper understanding of cellular resilience and vulnerability under pathological conditions. Furthermore, using these models can lead to the identification of potential therapeutic targets, providing a tangible pathway towards the development of novel interventions.
The scientific importance of PPP6R1 Gene Knockout Cell Lines extends into both research and clinical settings. They serve as reliable experimental platforms for drug screening, biomarker discovery, and the validation of therapeutic efficacy in targeted therapies. Given the increasing focus on personalized medicine and the role of phosphatases in cancer, these cell lines hold significant promise for translational research.
In comparison to alternative models such as wild-type or non-specified knockout lines, the specific targeting of the PPP6R1 gene offers unparalleled specificity and relevance. Researchers can trust these cell lines to deliver reproducible data that reflect true physiological conditions, thereby enhancing the reliability of their findings.
For researchers, clinicians, and pharmaceutical companies, PPP6R1 Gene Knockout Cell Lines represent a strategic asset in the quest for innovative solutions to complex diseases. The ability to investigate and manipulate key pathways opens avenues for groundbreaking discoveries. Our company specializes in producing high-quality biological products, ensuring that our cell lines are rigorously validated for research purposes, thereby supporting scientific advancement with reliable tools tailored for contemporary research needs.
Please note that all services are for research use only. Not intended for any clinical use.
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