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PIR Knockout Cell Lines

Gene: PIR

Official Full Name: pirinprovided by HGNC

Gene Summary: This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO34069 PIR Knockout cell line (HeLa) Human PIR 1:3~1:6 Negative Online Inquiry
KO34070 PIR Knockout cell line (HCT 116) Human PIR 1:2~1:4 Negative Online Inquiry
KO34071 PIR Knockout cell line (HEK293) Human PIR 1:3~1:6 Negative Online Inquiry
KO34072 PIR Knockout cell line (A549) Human PIR 1:3~1:4 Negative Online Inquiry

Background

PIR Gene Knockout Cell Lines are genetically engineered cell lines designed to provide researchers with a controlled environment to study gene function and related biological pathways by eliminating specific genes from the genome. This powerful tool utilizes CRISPR-Cas9 technology, which allows for precise editing of the genome, facilitating the systematic elimination of target genes. By observing the resulting phenotypic changes, researchers can gain invaluable insights into the roles of individual genes in various biological processes.

The primary function of PIR Gene Knockout Cell Lines lies in their ability to elucidate gene function and uncover the molecular mechanisms governing cellular behavior. When specific genes are knocked out, the resultant alterations in metabolic pathways, signal transduction, and cellular responses can be meticulously examined. This makes these cell lines indispensable in fields such as cancer research, pharmacology, and developmental biology where understanding gene function is critical for therapeutic advancements.

From a scientific perspective, these knockout models offer significant applications in both research and clinical settings. They can be employed for drug discovery, validation of therapeutic targets, and investigating the molecular underpinnings of diseases. Their utility extends to the identification of genetic markers for diseases, aiding personalized medicine initiatives.

Compared to alternative approaches such as RNA interference or traditional knockout methods, PIR Gene Knockout Cell Lines provide superior efficiency and specificity. The CRISPR technology used ensures high fidelity and minimal off-target effects, which enhances the reliability of experimental data and interpretations. Furthermore, unlike transient methods, these cell lines allow for stable gene knockouts, facilitating long-term studies.

For researchers and clinicians, the value of PIR Gene Knockout Cell Lines is manifold—they pave the way for groundbreaking discoveries and advancements in targeted therapies, ultimately improving patient outcomes. Our company is committed to delivering high-quality, cutting-edge biological products, backed by extensive expertise in genetic engineering and cell biology, ensuring that you have the best tools available to advance your research or clinical endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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