Home / PCSK6 Knockout Cell Lines

PCSK6 Knockout Cell Lines

Gene: PCSK6

Official Full Name: proprotein convertase subtilisin/kexin type 6provided by HGNC

Gene Summary: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. The encoded protease is constitutively secreted into the extracellular matrix and expressed in many tissues, including neuroendocrine, liver, gut, and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression and left-right patterning. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2014]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36238 PCSK6 Knockout cell line (HeLa) Human PCSK6 1:3~1:6 Negative Online Inquiry
KO36239 PCSK6 Knockout cell line (HCT 116) Human PCSK6 1:2~1:4 Negative Online Inquiry
KO36240 PCSK6 Knockout cell line (HEK293) Human PCSK6 1:3~1:6 Negative Online Inquiry
KO36241 PCSK6 Knockout cell line (A549) Human PCSK6 1:3~1:4 Negative Online Inquiry

Background

PCSK6 Gene Knockout Cell Lines are specially engineered cellular models that have had the proprotein convertase subtilisin/kexin type 6 (PCSK6) gene disrupted, enabling researchers to investigate the specific pathways and biological processes mediated by this enzyme. PCSK6 is a vital component in the cleavage and maturation of various proteins, playing a crucial role in the activation of peptide hormones and growth factors. The knockout of PCSK6 allows for the examination of its deleterious effects on cellular functions, such as cell signaling, proliferation, and differentiation, facilitating a comprehensive understanding of its contribution to various diseases.

The key function of PCSK6 Gene Knockout Cell Lines lies in their ability to demonstrate loss-of-function phenotypes that can elucidate the biological roles of PCSK6. By leveraging this genetic alteration, researchers can study how the absence of this convertase impacts critical physiological processes, potentially identifying novel therapeutic targets for conditions such as cancer and metabolic disorders. These cell lines serve as invaluable tools in drug discovery and development, allowing for the validation of therapeutic targets in a controlled environment.

From a scientific perspective, these knockout cell lines are critical for advancing our knowledge of proteolytic processing and its implications in health and disease. Compared to standard cell lines, the specific knockout of the PCSK6 gene offers researchers unparalleled clarity in experimental design, enhancing the reliability and accuracy of their findings.

The advantages of using PCSK6 Gene Knockout Cell Lines include their well-characterized genetic background, ability to provide reproducible results, and the opportunity to use them in various assays to assess cellular behavior influenced by PCSK6. This specificity not only reduces experimental variability but also enhances the potential for successful translational research applications.

Researchers and clinicians can benefit significantly from integrating these cell lines into their studies, as they represent a cutting-edge resource for uncovering the complexities of protein processing mechanisms in biological systems. The insights gained from PCSK6 research can contribute to innovative approaches to therapy and deepen our understanding of disease etiology.

Our company specializes in producing high-quality biological products, including well-validated gene knockout cell lines, supported by a commitment to rigorous scientific standards and customer satisfaction. With our expertise in cellular models, we equip researchers with the tools they need to catalyze scientific advancements.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.