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PCDH17 Knockout Cell Lines

Gene: PCDH17

Official Full Name: protocadherin 17provided by HGNC

Gene Summary: This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein contains six extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein may play a role in the establishment and function of specific cell-cell connections in the brain. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO27712 PCDH17 Knockout cell line (HEK293) Human PCDH17 1:3~1:6 Negative Online Inquiry

Background

PCDH17 Gene Knockout Cell Lines represent a cutting-edge tool in genetic research, designed specifically to facilitate the study of the protocadherin 17 gene, which is crucial for neural development and synaptic function. These engineered cell lines are characterized by the complete ablation of the PCDH17 gene, allowing researchers to investigate the gene's role in pathophysiological conditions and its implications for neurodevelopmental disorders.

The primary function of the PCDH17 Gene Knockout Cell Lines is to serve as a model for examining how the loss of PCDH17 affects cellular pathways, signaling mechanisms, and overall cell behavior. This is achieved through advanced CRISPR-Cas9 technology, which provides precision in gene editing, ensuring that the knockout is efficiently and reliably established. By studying these cell lines, researchers can elucidate the pathways influenced by PCDH17, thereby gaining insights into its contributions to cell adhesion and neural circuit formation.

The scientific relevance of these cell lines is profound, particularly in the realms of neuroscience and developmental biology. They are invaluable in research settings aimed at elucidating the molecular underpinnings of conditions such as autism spectrum disorders, schizophrenia, and other neurodevelopmental anomalies. The ability to model these complex diseases at the cellular level significantly enhances the understanding of their pathogenesis and opens avenues for potential therapeutic interventions.

What sets PCDH17 Gene Knockout Cell Lines apart from traditional models is their highly specific and efficient gene editing, which minimizes off-target effects and enhances the reliability of experimental outcomes. Furthermore, the adaptability of these cell lines allows researchers to conduct a variety of assay types—from drug screening to gene expression analysis—making them versatile tools for both foundational and applied research.

For researchers and clinicians, adopting PCDH17 Gene Knockout Cell Lines can lead to more definitive results, ultimately advancing the field of neuroscience. Our company prides itself on expertise in genetic engineering and the development of innovative biological products that meet the rigorous demands of modern research. With a commitment to quality and reliability, we provide products that empower scientists to make groundbreaking discoveries in their fields.

Please note that all services are for research use only. Not intended for any clinical use.

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