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OR11H7 Knockout Cell Lines

Gene: OR11H7

Official Full Name: olfactory receptor family 11 subfamily H member 7 (gene/pseudogene)provided by HGNC

Gene Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jan 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO15456 OR11H7 Knockout cell line (HeLa) Human OR11H7 1:3~1:6 Negative Online Inquiry
KO15457 OR11H7 Knockout cell line (HCT 116) Human OR11H7 1:2~1:4 Negative Online Inquiry
KO15458 OR11H7 Knockout cell line (HEK293) Human OR11H7 1:3~1:6 Negative Online Inquiry
KO15459 OR11H7 Knockout cell line (A549) Human OR11H7 1:3~1:4 Negative Online Inquiry

Background

OR11H7 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to facilitate the study of the OR11H7 gene, which encodes a receptor implicated in various physiological processes, including olfaction and neural signaling. Through advanced CRISPR-Cas9 technology, these knockout cell lines have been meticulously developed to eliminate the expression of the OR11H7 gene, allowing researchers to investigate the functional consequences of gene loss in a controlled and reproducible environment.

The OR11H7 gene knockout mechanism hinges on the targeted disruption of the gene’s coding sequence, which leads to a complete absence of the functional protein. This absence opens up valuable avenues for understanding the molecular pathways that are influenced by this receptor, thus providing insights into its roles in disease mechanisms, drug response, and system-level interactions. Such knockout models can elucidate how aberrations in the OR11H7 gene may contribute to various pathological conditions, furthering knowledge in areas such as neurobiology and pharmacogenomics.

In research and clinical settings, these cell lines are indispensable for drug development, enabling the screening of therapeutic compounds that modulate receptor activity. Compared to unmodified cell lines or other genetic manipulation techniques, OR11H7 Gene Knockout Cell Lines allow for precise control over gene expression and the resulting phenotypic variations, thereby providing clearer interpretations of experimental outcomes.

The specific advantages of using OR11H7 Gene Knockout Cell Lines range from enhanced reproducibility of experimental results to cost-effectiveness in large-scale screening assays. Their unique design reduces off-target effects commonly associated with traditional gene-editing methods, ensuring higher fidelity in experimental data. As such, these cell lines represent a crucial tool for researchers seeking to gain deeper insights into receptor biology and its implications in human diseases.

At [Your Company Name], we are dedicated to advancing molecular biology through innovative products and unparalleled expertise in genetic engineering. Our commitment to quality and scientific rigor ensures that researchers and clinicians receive reliable tools that push the boundaries of biological research.

Please note that all services are for research use only. Not intended for any clinical use.

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