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MYO9A Knockout Cell Lines

Gene: MYO9A

Official Full Name: myosin IXAprovided by HGNC

Gene Summary: This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. They function as actin-based molecular motors. Mutations in this gene have been associated with Bardet-Biedl Syndrome. [provided by RefSeq, Dec 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36492 MYO9A Knockout cell line (HeLa) Human MYO9A 1:3~1:6 Negative Online Inquiry
KO36493 MYO9A Knockout cell line (HCT 116) Human MYO9A 1:2~1:4 Negative Online Inquiry
KO36494 MYO9A Knockout cell line (HEK293) Human MYO9A 1:3~1:6 Negative Online Inquiry
KO36495 MYO9A Knockout cell line (A549) Human MYO9A 1:3~1:4 Negative Online Inquiry

Background

MYO9A Gene Knockout Cell Lines are specialized cellular models engineered for the targeted disruption of the MYO9A gene, which encodes the myosin IXA protein involved in various cellular processes, including cytoskeletal organization and cellular signaling. By employing CRISPR/Cas9 gene editing technology, these cell lines provide researchers with a powerful tool to elucidate the specific functions of MYO9A in a variety of biological contexts.

The primary function of MYO9A is to facilitate cellular movement and shape changes by interacting with the actin cytoskeleton. This is critical in processes such as cell migration, division, and intracellular transport. The knockout of MYO9A can reveal insights into its contribution to various cell behavior phenomena, illuminating pathways that may be involved in cancer metastasis, neurodegenerative diseases, and other disorders where cell motility plays a pivotal role.

From a scientific perspective, the MYO9A Gene Knockout Cell Lines are invaluable for a myriad of applications. These include drug discovery, development of therapeutic strategies, and studying disease models both in vitro and potentially in vivo. The ability to observe the phenotypic outcomes and molecular changes following the knockout of this gene allows for a greater understanding of cellular dynamics and pathophysiological conditions.

Unique advantages of using MYO9A Gene Knockout Cell Lines include their customizable nature and precise gene editing capabilities, which outperform traditional gene silencing techniques such as RNA interference (RNAi). Unlike RNAi, which can produce off-target effects and incomplete gene knockdown, CRISPR/Cas9 offers a definitive and permanent gene disruption, providing clearer insights into gene function.

Researchers and clinicians will find significant value in these knockout cell lines, as they enable the exploration of critical biological questions and the identification of novel therapeutic targets. As a product offered by our company, which prides itself on expertise in cellular engineering and gene editing technologies, MYO9A Gene Knockout Cell Lines represent our commitment to advancing research in cellular and molecular biology, ultimately contributing to improved health outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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