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MYC Knockout Cell Lines

Gene: MYC

Official Full Name: MYC proto-oncogene, bHLH transcription factorprovided by HGNC

Gene Summary: This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00389 MYC gRNA1-gRNA2 KO plasmid MYC $850
GP00449 MYC gRNA3-gRNA4 KO plasmid MYC $850
KO00758 MYC Knockout cell line (HEK293) Human MYC 1:3~1:6 Negative Online Inquiry

Background

MYC Gene Knockout Cell Lines are specially engineered cellular systems designed to explore the functional role of the MYC gene, a key regulator of cell proliferation, differentiation, and metabolism. These cell lines are generated using advanced CRISPR-Cas9 technology to create precise knockouts, effectively removing the MYC gene's expression and allowing researchers to study the consequent biological changes.

The primary function of MYC Gene Knockout Cell Lines is to serve as a powerful tool for investigating the pathways involved in cell growth and cancer development. By eliminating the MYC gene, researchers can observe alterations in cellular behavior, including apoptosis, metabolic changes, and genomic stability. These cell lines facilitate extensive studies into the molecular mechanisms that underlie various diseases, particularly cancer, where MYC overexpression is often implicated.

From a scientific standpoint, MYC Gene Knockout Cell Lines hold significant applications in both research and clinical settings. They are invaluable for drug discovery, enabling the screening of compounds that can target MYC-dependent pathways. Additionally, these models can be utilized to validate therapeutic targets by providing insights into how MYC signaling contributes to malignancy and resistance to treatment, thereby informing more effective therapeutic strategies.

Compared to traditional cell lines that maintain MYC expression, our MYC Gene Knockout Cell Lines provide enhanced specificity and control. This allows for the elimination of confounding variables often present in non-modified systems, resulting in clearer, more interpretable data. Furthermore, these cell lines have been validated for consistent performance, ensuring reproducibility and reliability across experiments.

For researchers and clinicians, the availability of MYC Gene Knockout Cell Lines offers a critical advantage in the pursuit of innovative cancer therapies and a deeper understanding of oncogenic processes. By employing this product, users will access the tools necessary to unravel complex biological mechanisms and contribute to the advancement of therapeutic interventions.

Our company has a proven track record in developing cutting-edge biological products that meet the highest standards of quality and innovation. By leveraging our extensive expertise in genetic engineering, we deliver reliable and effective research solutions that empower scientists in their quest for discovery and advancement in the field of molecular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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