Gene: MMD
Official Full Name: monocyte to macrophage differentiation associatedprovided by HGNC
Gene Summary: This protein is expressed by in vitro differentiated macrophages but not freshly isolated monocytes. Although sequence analysis identifies seven potential transmembrane domains, this protein has little homology to G-protein receptors and it has not been positively identified as a receptor. A suggested alternative function is that of an ion channel protein in maturing macrophages. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO29185 | MMD Knockout cell line (HeLa) | Human | MMD | 1:3~1:6 | Negative | Online Inquiry |
KO29186 | MMD Knockout cell line (HCT 116) | Human | MMD | 1:2~1:4 | Negative | Online Inquiry |
KO29187 | MMD Knockout cell line (HEK293) | Human | MMD | 1:3~1:6 | Negative | Online Inquiry |
KO29188 | MMD Knockout cell line (A549) | Human | MMD | 1:3~1:4 | Negative | Online Inquiry |
MMD Gene Knockout Cell Lines are specialized cell lines in which the MMD gene has been effectively disrupted or "knocked out." These engineered cell models serve as powerful tools for investigating gene function, gene regulation, and the phenotypic consequences of losing MMD expression. Through targeted CRISPR-Cas9 technology, these cell lines allow for precise alterations of the genome, enabling researchers to dissect the biological roles of MMD in various physiological and pathological contexts.
The primary mechanism of action for these knockout cell lines involves the introduction of double-strand breaks at specific loci in the MMD gene, followed by the cell's natural repair mechanisms, which result in the deletion or alteration of the target gene. This process leads to a complete absence of MMD protein expression, providing a unique opportunity to study its role in cellular pathways such as signal transduction, metabolism, and immune response.
Scientifically, MMD Gene Knockout Cell Lines are invaluable in basic research, allowing scientists to elucidate the underlying mechanisms of diseases where MMD might play a critical role, including cancer and metabolic disorders. Their applications extend to drug discovery and development, wherein researchers can utilize these lines to screen for potential therapeutic compounds targeting pathways influenced by MMD.
Compared to traditional gene silencing methods like RNA interference, which can yield only transient effects, MMD Gene Knockout Cell Lines offer stable and persistent gene disruption, making them more suitable for long-term studies. Additionally, the high specificity of the CRISPR-Cas9 system minimizes off-target effects, providing a clearer understanding of the biological implications of gene knockout.
For researchers and clinicians aiming to accelerate their investigation into the MMD gene, these knockout cell lines are a crucial asset. They enable an in-depth analysis of gene function and provide robust platforms for therapeutic explorations.
As leaders in biological research tools, our company is committed to providing high-quality, expertly developed products like MMD Gene Knockout Cell Lines, ensuring that researchers have the necessary resources to advance their scientific inquiries successfully.
Please note that all services are for research use only. Not intended for any clinical use.
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