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MISP Knockout Cell Lines

Gene: MISP

Official Full Name: mitotic spindle positioningprovided by HGNC

Gene Summary: The protein encoded by this gene is an actin-bundling protein involved in determining cell morphology and mitotic progression. The encoded protein is required for the proper positioning of the mitotic spindle. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Feb 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03755 MISP Knockout cell line (HeLa) Human MISP 1:3~1:6 Negative Online Inquiry
KO03756 MISP Knockout cell line (HCT 116) Human MISP 1:2~1:4 Negative Online Inquiry
KO03757 MISP Knockout cell line (A549) Human MISP 1:3~1:4 Negative Online Inquiry

Background

MISP Gene Knockout Cell Lines are genetically modified cell lines specifically designed to study the function of the MISP gene, which encodes a protein involved in various cellular processes including mitosis and cell differentiation. These cell lines are created using CRISPR-Cas9 gene-editing technology to ensure precise and efficient knockout of the MISP gene, enabling researchers to explore the impact of its absence on cellular behavior and signaling pathways.

The key mechanism behind these cell lines involves the targeted disruption of the MISP gene, resulting in a loss-of-function phenotype. Researchers can utilize these knockout models to investigate the role of the MISP protein in cell cycle regulation, development, and disease progression, especially in cancer biology where aberrations in cell division and growth are critical. By analyzing how these modifications affect cellular dynamics and biological processes, scientists gain invaluable insights into the gene’s involvement in pathological states and therapeutic responses.

The scientific importance of MISP Gene Knockout Cell Lines is underscored by their applications in both fundamental and translational research. They serve as crucial tools for drug discovery and preclinical studies, allowing for the identification of potential therapeutic targets and the assessment of drug efficacy in MISP-deficient cells. Additionally, these cell lines facilitate the understanding of genetic interactions and the functional consequences of gene mutations in various disease contexts.

Compared to traditional cell lines that may not precisely capture the biological relevance of MISP gene function, MISP Gene Knockout Cell Lines provide a specific and accurate model. They reduce variability in experimental outcomes, allowing for higher reproducibility and reliability in research findings. Furthermore, the CRISPR-Cas9 efficiency ensures that these cell lines maintain the desired genetic modifications over extended periods, enhancing their utility in longitudinal studies.

Researchers, clinicians, and biotechnology companies can derive substantial value from using MISP Gene Knockout Cell Lines due to their ability to dissect complex biological questions related to cell proliferation and pathology. The precision and versatility of these models enable advancements not just in academic research but also in the development of targeted treatments in clinical settings.

In summary, at [Your Company Name], we pride ourselves on offering high-quality biological products tailored for advanced research and clinical applications, backed by a team of experts committed to innovation and excellence in gene-editing technologies. Our MISP Gene Knockout Cell Lines stand as a testament to our dedication to empowering researchers in their exploration of intricate biological systems.

Please note that all services are for research use only. Not intended for any clinical use.

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