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MBNL3 Knockout Cell Lines

Gene: MBNL3

Official Full Name: muscleblind like splicing regulator 3provided by HGNC

Gene Summary: This gene encodes a member of the muscleblind-like family of proteins. The encoded protein may function in regulation of alternative splicing and may play a role in the pathophysiology of myotonic dystrophy. Alternatively spliced transcript variants have been described. [provided by RefSeq, Dec 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO16310 MBNL3 Knockout cell line (HeLa) Human MBNL3 1:3~1:6 Negative Online Inquiry
KO16311 MBNL3 Knockout cell line (HCT 116) Human MBNL3 1:2~1:4 Negative Online Inquiry
KO16312 MBNL3 Knockout cell line (HEK293) Human MBNL3 1:3~1:6 Negative Online Inquiry

Background

MBNL3 Gene Knockout Cell Lines are specially developed cellular models containing a targeted mutation in the MBNL3 gene, facilitating the study of alternative splicing and gene regulation processes in various biological contexts. By utilizing CRISPR/Cas9 technology to create these knockout lines, researchers can explore the functional importance of MBNL3 in cell biology, disease mechanisms, and therapeutic strategies, thereby elucidating its role in development and disease pathways.

The primary function of MBNL3 is its involvement in RNA binding and alternative splicing regulation, which is critical for cellular adaptation to various physiological conditions. The knockout of MBNL3 allows for the dissection of its contributions to splicing events, cellular signaling, and the resulting phenotypic consequences. In doing so, these cell lines also enable researchers to elucidate the intricate interactions between MBNL3 and other splicing regulators and to assess the effects of MBNL3 loss on gene expression profiles quantitatively.

Scientifically, MBNL3 gene knockout cell lines have significant implications in both basic and applied research. They serve as pivotal tools for studying diseases such as myotonic dystrophy and other conditions linked to splicing dysregulation, paving the way for potential therapeutic innovations. Additionally, these cell lines can contribute to understanding tissue-specific roles of splicing factors during development and in disease states, ultimately aiding in the progression of personalized medicine.

Compared to alternative models, our MBNL3 Gene Knockout Cell Lines provide high reliability, consistency, and ease of use, facilitating reproducible results across various experimental setups. Harnessing the latest gene-editing techniques, these cell lines are positioned to deliver superior insights compared to conventional methods that may be limited in specificity.

For researchers and clinicians dedicated to advancing understanding of gene regulation and its impact on health, our MBNL3 knockouts are invaluable. They not only streamline research endeavors but also enhance the potential for groundbreaking discoveries, ultimately contributing to the development of novel therapeutic approaches. Backed by our commitment to innovation and excellence in biological products, we offer expert support and resources to ensure the successful application of our products in your research or clinical practice.

Please note that all services are for research use only. Not intended for any clinical use.

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