Gene: MAP2K7
Official Full Name: mitogen-activated protein kinase kinase 7provided by HGNC
Gene Summary: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO10713 | MAP2K7 Knockout cell line (HeLa) | Human | MAP2K7 | 1:3~1:6 | Negative | Online Inquiry |
KO10714 | MAP2K7 Knockout cell line (HCT 116) | Human | MAP2K7 | 1:2~1:4 | Negative | Online Inquiry |
KO10715 | MAP2K7 Knockout cell line (HEK293) | Human | MAP2K7 | 1:3~1:6 | Negative | Online Inquiry |
KO10716 | MAP2K7 Knockout cell line (A549) | Human | MAP2K7 | 1:3~1:4 | Negative | Online Inquiry |
MAP2K7 Gene Knockout Cell Lines are genetically modified cell lines in which the MAP2K7 gene, also known as mitogen-activated protein kinase kinase 7, has been selectively disrupted. This product serves as a powerful tool for researchers exploring the MAPK signaling pathways, which play pivotal roles in various cellular processes, including cell division, differentiation, and response to stress. The knockout of MAP2K7 provides a means to study its specific contributions to cellular functions and assess its impact on downstream signaling molecules.
The primary function of MAP2K7 is to act as an upstream activator in the JNK (c-Jun N-terminal kinase) signaling pathway, which is crucial in mediating cellular responses to stress and inflammation. By utilizing these knockout cell lines, researchers can investigate the effects of MAP2K7 loss on cellular proliferation, apoptosis, and even cancer progression, providing insights into therapeutic targets for diseases where this pathway is dysregulated.
The scientific importance of MAP2K7 Gene Knockout Cell Lines extends to both basic research and clinical applications. In research settings, they enable detailed studies of gene function and pathway interactions, while in clinical contexts, they can contribute to the development of targeted therapies by elucidating the roles of MAP2K7 in pathological conditions such as cancer or autoimmune diseases.
One of the unique advantages of our MAP2K7 Gene Knockout Cell Lines is the high specificity and efficiency of the gene editing process. Unlike traditional knockout methods, which can lead to off-target effects, our proprietary techniques ensure that the MAP2K7 gene is precisely and reliably disrupted, resulting in more reproducible experimental outcomes. This level of accuracy is crucial for obtaining valid results that can inform both basic science and therapeutic innovations.
For researchers and clinicians aiming to deepen their understanding of MAP2K7's role in biology or to develop new treatments, these knockout cell lines represent a valuable resource. Our commitment to quality and innovation in biological products underscores our expertise in genetic engineering, making us a trusted partner in advancing scientific knowledge and improving patient outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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