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MAP2K2 Knockout Cell Lines

Gene: MAP2K2

Official Full Name: mitogen-activated protein kinase kinase 2provided by HGNC

Gene Summary: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, cognitive disability, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10725 MAP2K2 Knockout cell line (HeLa) Human MAP2K2 1:3~1:6 Negative Online Inquiry
KO10726 MAP2K2 Knockout cell line (HCT 116) Human MAP2K2 1:2~1:4 Negative Online Inquiry
KO10727 MAP2K2 Knockout cell line (HEK293) Human MAP2K2 1:3~1:6 Negative Online Inquiry
KO10728 MAP2K2 Knockout cell line (A549) Human MAP2K2 1:3~1:4 Negative Online Inquiry

Background

MAP2K2 Gene Knockout Cell Lines represent a cutting-edge tool in molecular biology, specifically designed to facilitate the study of the MAP2K2 gene, which encodes for the mitogen-activated protein kinase kinase 2 (MEK2) protein. These cell lines have been meticulously engineered to possess targeted disruptions in the MAP2K2 gene, enabling researchers to examine the downstream effects of MEK2 signaling in various cellular contexts. By studying these knockout cell lines, scientists can elucidate the biochemical pathways regulated by MEK2 and its role in essential cellular processes such as proliferation, differentiation, and apoptosis.

The key mechanism underlying the utility of these knockout cell lines lies in their ability to provide a controlled environment for observing the effects of MEK2 deficiency. With the absence of functional MAP2K2, researchers can accurately determine the biological consequences of inhibiting this pathway, allowing for the investigation of its implications in disease states such as cancer, neurological disorders, and autoimmune diseases. Because MEK2 is a pivotal component of the MAPK/ERK signaling cascade, these cell lines are indispensable for both basic research and the development of targeted therapeutics.

In comparison to wild-type cell lines or alternative gene editing tools, MAP2K2 Gene Knockout Cell Lines offer distinct advantages. They provide a reliable and stable model for studying gene function, are straightforward to use, and require minimal optimization. This not only saves time for researchers but also enhances reproducibility across experiments. Additionally, the specificity of the knockout ensures that observed phenotypes can be directly attributed to the absence of MAP2K2, minimizing confounding factors.

Researchers and clinicians alike will find immense value in these knockout cell lines, as they open new avenues for investigating signaling pathways and developing innovative therapies. The ability to dissect the roles of specific genes in health and disease is crucial for advancing the field of personalized medicine.

Our company specializes in providing high-quality, validated biological research products, and MAP2K2 Gene Knockout Cell Lines are a testament to our commitment to enhancing scientific discovery and clinical advancements. With a focus on precision and reliability, we aim to empower researchers to pursue groundbreaking work that addresses the complexities of human biology.

Please note that all services are for research use only. Not intended for any clinical use.

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