Gene: KDM7A
Official Full Name: lysine demethylase 7Aprovided by HGNC
Gene Summary: Enables histone demethylase activity; methylated histone binding activity; and transition metal ion binding activity. Predicted to be involved in chromatin remodeling; midbrain development; and regulation of transcription by RNA polymerase II. Located in nucleolus and nucleoplasm. Implicated in melanoma. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO25859 | KDM7A Knockout cell line (HeLa) | Human | KDM7A | 1:3~1:6 | Negative | Online Inquiry |
KO25860 | KDM7A Knockout cell line (HCT 116) | Human | KDM7A | 1:2~1:4 | Negative | Online Inquiry |
KO25861 | KDM7A Knockout cell line (HEK293) | Human | KDM7A | 1:3~1:6 | Negative | Online Inquiry |
KO25862 | KDM7A Knockout cell line (A549) | Human | KDM7A | 1:3~1:4 | Negative | Online Inquiry |
KDM7A Gene Knockout Cell Lines are genetically engineered cell lines created by specifically targeting and disrupting the KDM7A gene, which encodes for a lysine demethylase that plays a crucial role in epigenetic regulation. By facilitating the removal of methyl groups from lysine residues on histone proteins, KDM7A modulates chromatin structure and gene expression, influencing cellular processes such as differentiation, proliferation, and transcriptional regulation.
The principal function of these knockout cell lines lies in their ability to provide researchers with a powerful tool for unraveling the molecular details of KDM7A's role in various biological contexts. The lack of KDM7A allows for the study of its pathway interactions and downstream effects in cellular behavior, thereby aiding in elucidating its function in development and disease. This capability is particularly valuable in oncology, as aberrations in epigenetic regulation are often linked to tumorigenesis.
The scientific importance of KDM7A Gene Knockout Cell Lines extends to their application in both basic research and clinical studies, where they help to model human diseases and explore therapeutic targets. The knockout model enables the investigation of gene function in a controlled environment, making it an indispensable tool for drug discovery and developing targeted therapies.
Compared to traditional gene editing approaches, such as CRISPR or siRNA, KDM7A Gene Knockout Cell Lines offer the advantage of a stable genomic modification that is passed on through cell divisions. This stability facilitates long-term studies and reduces variability associated with transient knockdown methods. Additionally, these cell lines can be used in a variety of experimental systems, making them adaptable to diverse research needs.
For researchers and clinicians looking to explore the intricate roles of KDM7A in cellular processes and disease mechanisms, the KDM7A Gene Knockout Cell Lines present an invaluable asset. With a commitment to providing high-quality genetic tools, our company leverages advanced genomic technologies and deep scientific expertise to offer robust solutions, empowering you to advance your research and discovery with confidence.
Please note that all services are for research use only. Not intended for any clinical use.
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