Gene: KCNIP3
Official Full Name: potassium voltage-gated channel interacting protein 3provided by HGNC
Gene Summary: This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO26748 | KCNIP3 Knockout cell line (HCT 116) | Human | KCNIP3 | 1:2~1:4 | Negative | Online Inquiry |
KO26749 | KCNIP3 Knockout cell line (HEK293) | Human | KCNIP3 | 1:3~1:6 | Negative | Online Inquiry |
KCNIP3 Gene Knockout Cell Lines are specialized cellular models in which the KCNIP3 gene has been deliberately interrupted or inactivated, providing researchers with a powerful tool to study the functional consequences of gene loss. KCNIP3, encoding for the K+ channel interacting protein 3, plays a significant role in modulating neuronal excitability and synaptic function, making these knockout cell lines invaluable for investigating neurobiological processes and pathways involved in various neurological disorders.
The primary function of these knockout cell lines is to facilitate the exploration of the gene's role in cellular signaling and its implications in disease models. By eliminating KCNIP3 expression, researchers can pinpoint alterations in ionic currents, calcium signaling, and neurotransmitter release that are critical for understanding synaptic plasticity and neuronal health. This allows for a more nuanced investigation into conditions such as epilepsy, mood disorders, and neurodegenerative diseases.
These cell lines hold significant scientific importance in both research and clinical settings. They provide a platform for drug screening, gene therapy developments, and the study of gene-environment interactions. With the ongoing demand for precise models that mimic human physiological responses, KCNIP3 Gene Knockout Cell Lines represent a step forward in translational medicine, bridging laboratory findings to clinical applications.
Compared to traditional models, KCNIP3 knockout lines offer specific advantages, including a clear genetic alteration, consistency in cellular behavior, and enhanced reproducibility across experiments. Unlike other generic knockout systems, our specialized KCNIP3 cell lines ensure a targeted approach to understanding KCNIP3-mediated mechanisms, eliminating the variability often associated with less specific models.
For researchers and clinicians focused on neurobiology and related therapeutic areas, these cell lines offer invaluable insights, enabling them to make significant strides in understanding and treating brain-related disorders. Our company prides itself on delivering high-quality biological products, backed by rigorous validation and an established history of supporting cutting-edge research. Through our expertise and commitment, we empower the scientific community with the tools necessary to advance discovery and innovation.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.