Gene: IL27RA
Official Full Name: interleukin 27 receptor subunit alphaprovided by HGNC
Gene Summary: In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO11263 | IL27RA Knockout cell line (HeLa) | Human | IL27RA | 1:3~1:6 | Negative | Online Inquiry |
KO11264 | IL27RA Knockout cell line (HCT 116) | Human | IL27RA | 1:2~1:4 | Negative | Online Inquiry |
KO11265 | IL27RA Knockout cell line (HEK293) | Human | IL27RA | 1:3~1:6 | Negative | Online Inquiry |
KO11266 | IL27RA Knockout cell line (A549) | Human | IL27RA | 1:3~1:4 | Negative | Online Inquiry |
IL27RA Gene Knockout Cell Lines are specialized cellular models engineered to facilitate the study of the Interleukin 27 Receptor A (IL27RA) gene, a critical component in the regulation of immune response and inflammation. Through the precise application of CRISPR-Cas9 gene-editing technology, these knockout cell lines have been created to eliminate the expression of IL27RA, allowing researchers to explore the gene’s specific contributions in various biological processes.
The mechanism of action for these cell lines revolves around the absence of functional IL27RA, which is known to bind to the cytokine IL-27. This receptor-ligand interaction is essential for mediating immune responses, influencing T cell differentiation, and modulating inflammatory pathways. By utilizing these knockout cell lines, scientists can investigate the multifaceted role of IL27RA in diseases such as autoimmune disorders, cancer, and infections, offering insights into potential therapeutic targets.
The utility of IL27RA Gene Knockout Cell Lines in research environments is significant; they serve as invaluable tools for drug discovery, functional assays, and pathway elucidation. Their application extends to both basic and applied sciences, where understanding the nuances of IL27RA's role can lead to groundbreaking advancements in immunotherapy and personalized medicine.
What sets our IL27RA Gene Knockout Cell Lines apart from alternative models is the high efficiency and specificity of our CRISPR methodology, ensuring reliable results that are reproducible across experiments. Furthermore, these cell lines are extensively validated and characterized, providing researchers with confidence in their findings.
The value of IL27RA Gene Knockout Cell Lines extends beyond mere research; they represent a bridge to innovative therapeutic approaches for diseases characterized by aberrant immune responses. By utilizing these cutting-edge tools, researchers and clinicians can advance their understanding and develop effective interventions.
Our company boasts a robust portfolio of gene-editing products and a rich history of supporting scientific discovery. With expertise in developing high-quality biological products, we are committed to empowering researchers in their pursuit of scientific excellence.
Please note that all services are for research use only. Not intended for any clinical use.
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