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GRAMD1A Knockout Cell Lines

Gene: GRAMD1A

Official Full Name: GRAM domain containing 1Aprovided by HGNC

Gene Summary: Predicted to enable cholesterol binding activity and cholesterol transfer activity. Predicted to be involved in cellular response to cholesterol and intracellular sterol transport. Located in several cellular components, including cytosol; endoplasmic reticulum membrane; and organelle membrane contact site. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO17273 GRAMD1A Knockout cell line (HeLa) Human GRAMD1A 1:3~1:6 Negative Online Inquiry
KO17274 GRAMD1A Knockout cell line (HCT 116) Human GRAMD1A 1:2~1:4 Negative Online Inquiry
KO17275 GRAMD1A Knockout cell line (HEK293) Human GRAMD1A 1:3~1:6 Negative Online Inquiry
KO17276 GRAMD1A Knockout cell line (A549) Human GRAMD1A 1:3~1:4 Negative Online Inquiry

Background

GRAMD1A Gene Knockout Cell Lines are genetically engineered cell models specifically designed to study the functional implications of the GRAMD1A gene, which is implicated in lipid homeostasis and cellular signaling pathways. These knockout cell lines are constructed using CRISPR/Cas9 technology to facilitate precise and efficient gene editing, allowing for the complete ablation of the GRAMD1A gene expression.

The primary function of GRAMD1A is to mediate lipid interactions within cells, making it a critical component in the regulation of lipid metabolism and cellular responses to stress. By utilizing GRAMD1A knockout cell lines, researchers can investigate how the absence of this gene affects cellular functions, including lipid uptake and release, apoptosis, and the cellular response to metabolic disorders. The cell lines serve as a vital tool for elucidating the role of GRAMD1A in various physiological and pathological contexts, thereby contributing to our understanding of diseases such as obesity, diabetes, and atherosclerosis.

In terms of scientific importance, these knockout models can be instrumental in drug discovery and development, as they allow researchers to identify potential therapeutic targets and evaluate drug efficacy in a controlled environment. Additionally, GRAMD1A knockout cell lines can be utilized in academic and industrial research settings to develop novel strategies for the treatment of metabolic diseases.

What sets our GRAMD1A knockout cell lines apart from alternative models is their high fidelity in representing the GRAMD1A deficiency, along with extensive validation and characterization to ensure reliability in experimental outcomes. This precision enables researchers to obtain consistent and reproducible data, making our product a trusted choice for serious inquiries into lipid biology.

For researchers and clinicians aiming to unveil the complexities of lipid-related diseases, GRAMD1A Gene Knockout Cell Lines offer a unique and powerful approach. By partnering with us, you gain access to not only expertly engineered cell lines but also our unwavering commitment to scientific excellence and continual support for your research endeavors. Our team of experienced scientists is dedicated to providing premium biological products that meet the highest standards, ensuring your research can thrive.

Please note that all services are for research use only. Not intended for any clinical use.

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