Gene: GGT5
Official Full Name: gamma-glutamyltransferase 5provided by HGNC
Gene Summary: This gene is a member of the gamma-glutamyl transpeptidase gene family, and some reports indicate that it is capable of cleaving the gamma-glutamyl moiety of glutathione. The protein encoded by this gene is synthesized as a single, catalytically-inactive polypeptide, that is processed post-transcriptionally to form a heavy and light subunit, with the catalytic activity contained within the small subunit. The encoded enzyme is able to convert leukotriene C4 to leukotriene D4, but appears to have distinct substrate specificity compared to gamma-glutamyl transpeptidase. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO03431 | GGT5 Knockout cell line (HEK293) | Human | GGT5 | 1:3~1:6 | Negative | Online Inquiry |
GGT5 Gene Knockout Cell Lines are engineered cellular models specifically designed to investigate the biological and pathological roles of the gamma-glutamyl transferase 5 (GGT5) gene. This gene is known for its involvement in glutathione metabolism and cellular oxidative stress responses, making it of significant interest in cancer research and other oxidative stress-related diseases. By creating knockout variants where GGT5 expression is silenced, researchers can effectively assess the functional consequences of this gene's absence, including changes in cellular proliferation, survival pathways, and response to pharmacological agents.
The key mechanism of GGT5 Knockout Cell Lines involves the precise deletion of the GGT5 gene using advanced gene-editing techniques such as CRISPR/Cas9. This results in a robust model that enables scientists to study the specific pathways affected by GGT5 loss, providing insights into its role in tumorigenesis and therapeutic resistance. In research settings, these cell lines serve as critical tools for uncovering novel therapeutic targets and biomarkers, allowing for more targeted drug development.
The scientific importance of GGT5 Gene Knockout Cell Lines extends beyond fundamental research; they hold clinical relevance in the evaluation of anticancer therapies and other interventions designed to mitigate oxidative stress. By utilizing these cell lines, researchers can elucidate the mechanisms that underlie drug efficacy and resistance, thereby improving patient outcomes.
One of the standout advantages of our GGT5 Gene Knockout Cell Lines is their unparalleled purity and validated genetic modification, ensuring reproducibility and reliability across various experimental conditions. Unlike other models that may yield inconsistent results due to uncharacterized genetic backgrounds, our cell lines provide a precise tool for targeted investigations.
For researchers and clinicians focused on oxidative stress, cellular signaling, and cancer biology, these cell lines represent invaluable assets in translational research. Their ability to provide deeper insights into the role of GGT5 positions them as a critical component in the development of innovative therapeutic strategies.
Our company stands at the forefront of genetic engineering and cell line development, with a commitment to providing high-quality biological products that empower researchers to make breakthroughs in their fields. With our robust expertise and continuous innovation, we strive to deliver solutions that advance scientific understanding and clinical practice.
Please note that all services are for research use only. Not intended for any clinical use.
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