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GAK Knockout Cell Lines

Gene: GAK

Official Full Name: cyclin G associated kinaseprovided by HGNC

Gene Summary: In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37745 GAK Knockout cell line (HeLa) Human GAK 1:3~1:6 Negative Online Inquiry
KO37746 GAK Knockout cell line (HCT 116) Human GAK 1:2~1:4 Negative Online Inquiry
KO37747 GAK Knockout cell line (HEK293) Human GAK 1:3~1:6 Negative Online Inquiry
KO37748 GAK Knockout cell line (A549) Human GAK 1:3~1:4 Negative Online Inquiry

Background

GAK Gene Knockout Cell Lines are a specialized set of genetically engineered cell lines in which the GAK (cyclin G-associated kinase) gene has been intentionally disrupted or "knocked out." This innovative product serves as a vital tool for researchers investigating the biological functions of GAK and its implications in various cellular processes, including endocytosis, cell cycle regulation, and viral pathogenesis. By using CRISPR-Cas9 or similar genome-editing technologies, these cell lines facilitate precise manipulation of genetic material, enabling studies on the role of GAK in health and disease.

The mechanism by which these knockout cell lines operate involves the establishment of a stable genetic alteration that results in the absence of GAK expression. This allows researchers to observe the resultant phenotypic changes and analyze the downstream effects on signaling pathways and cellular functions. Such insights are critical for understanding the role of GAK in cancer proliferation, neuronal function, or innate immune responses, making these cell lines invaluable for basic research and translational studies alike.

In the realm of scientific inquiry, GAK Gene Knockout Cell Lines offer unparalleled opportunities for elucidating the roles of GAK in multiple biological contexts. Their precise genetic alterations provide a robust framework for drug development, target validation, and the identification of novel therapeutic strategies in clinical settings. Unlike conventional approaches, this knockout model delivers a higher specificity and reproducibility in experimental outcomes, thus enhancing the quality of data obtained.

Additionally, the GAK Gene Knockout Cell Lines stand out due to their ease of use and integration with high-throughput screening platforms, facilitating rapid experimentation and analysis. Researchers and clinicians can benefit from reduced time frames in project cycles and increased throughput, which ultimately translates to accelerated discovery and development processes.

As leaders in the field of genetic engineering, our company is committed to providing high-quality, reliable biological tools that empower scientific research and clinical advancements. With our expertise in gene editing and a wide array of innovative products, we enable researchers and clinicians to drive progress in their work, furthering our collective understanding of complex biological systems.

Please note that all services are for research use only. Not intended for any clinical use.

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