Home / GAGE8 Knockout Cell Lines

GAGE8 Knockout Cell Lines

Gene: GAGE8

Official Full Name: G antigen 8provided by HGNC

Gene Summary: This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions. The antigenic peptide YRPRPRRY, which is also encoded by several other family members, is recognized by autologous cytolytic T lymphocytes. [provided by RefSeq, Jul 2008]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO17489 GAGE8 Knockout cell line (HeLa) Human GAGE8 1:3~1:6 Negative Online Inquiry
KO17490 GAGE8 Knockout cell line (HCT 116) Human GAGE8 1:2~1:4 Negative Online Inquiry
KO17491 GAGE8 Knockout cell line (HEK293) Human GAGE8 1:3~1:6 Negative Online Inquiry
KO17492 GAGE8 Knockout cell line (A549) Human GAGE8 1:3~1:4 Negative Online Inquiry

Background

GAGE8 Gene Knockout Cell Lines are genetically engineered cellular models specifically designed to investigate the functional roles of the GAGE8 gene, which is implicated in various biological processes including cancer progression and immune responses. These knockout cell lines facilitate targeted studies by silencing the GAGE8 gene, allowing researchers to analyze the resultant phenotypes and molecular signaling pathways altered by this genetic modification.

Mechanistically, the creation of GAGE8 knockout cells involves utilizing CRISPR-Cas9 technology to induce double-strand breaks at the GAGE8 locus, which are subsequently repaired by non-homologous end joining, leading to gene disruption. This precise gene editing capability ensures a high specificity and efficiency in knocking out the gene, making it an invaluable tool for assaying the effects of GAGE8 absence on cellular behaviors such as proliferation, migration, and apoptosis.

From a scientific perspective, GAGE8 Gene Knockout Cell Lines are vital for elucidating the role of GAGE8 in both normal physiology and pathology, thus offering insights into potential therapeutic targets for cancer and other related diseases. Their application extends into drug discovery, biomarker identification, and personalized medicine, bridging fundamental research and clinical relevance.

One of the key advantages of our GAGE8 knockout cell lines is their ready-to-use status, which accelerates the research process, thereby saving time and resources for laboratories. Additionally, these cell lines undergo rigorous validation to ensure reproducibility and reliability in experimental outcomes, setting them apart from competitors that may offer less thoroughly characterized models.

For researchers and clinicians aiming to translate basic findings into clinical applications, the GAGE8 Gene Knockout Cell Lines present an instrumental resource. By enabling a clearer understanding of genetic influences on disease, this product empowers users to innovate and refine therapeutic strategies effectively.

Our company is committed to advancing scientific research through robust biological products, underscoring our expertise in cell line development and genetic engineering. Our dedication to quality assurance and user support ensures that customers receive optimal products tailored to their specific research needs.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.