Gene: FXYD1
Official Full Name: FXYD domain containing ion transport regulator 1provided by HGNC
Gene Summary: This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity. Transcript variants with different 5' UTR sequences have been described in the literature. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO07541 | FXYD1 Knockout cell line (HCT 116) | Human | FXYD1 | 1:2~1:4 | Negative | Online Inquiry |
KO07542 | FXYD1 Knockout cell line (HEK293) | Human | FXYD1 | 1:3~1:6 | Negative | Online Inquiry |
FXYD1 Gene Knockout Cell Lines are specialized cellular models created to study the functional role of the FXYD1 gene, which encodes a protein critical for ion transport regulation in various physiological processes. These cell lines have been engineered via CRISPR/Cas9 technology to have a complete knockout of the FXYD1 gene, making them invaluable tools for elucidating the gene's contributions to cellular homeostasis and signaling.
The primary function of these knockout cell lines is to facilitate the exploration of FXYD1's role in various biological processes, including epithelial ion transport, cellular pH regulation, and their potential implications in diseases such as hypertension and cystic fibrosis. By observing the physiological and molecular alterations in these modified cells, researchers can better understand how disruptions in FXYD1 may lead to pathophysiological conditions, providing insights into therapeutic intervention points.
From a scientific perspective, these cell lines offer an innovative platform for drug screening and biomarker discovery in clinical settings. Their defined genetic background allows for reproducible and comparative studies across different experimental conditions, thus aiding in the validation of FXYD1-targeted therapies. Additionally, FXYD1 knockout cell lines can be utilized in combinatorial studies to dissect interaction pathways involving ion transport and other signaling molecules.
One of the main advantages of FXYD1 Gene Knockout Cell Lines is their ability to present clear in vitro models that accurately reflect the functional loss of a specific gene, enabling straightforward interpretation of results. Unlike conventional knockdown techniques, which can lead to partial suppression and variability in gene expression, complete knockout offers a reliable foundation for experimental design and outcome analysis.
This product is particularly valuable to researchers and clinicians focused on ion transport mechanisms, disease pathogenesis, and drug development, affording them a unique opportunity to harness high-fidelity cellular models for advanced studies.
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Please note that all services are for research use only. Not intended for any clinical use.
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