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FOXN4 Knockout Cell Lines

Gene: FOXN4

Official Full Name: forkhead box N4provided by HGNC

Gene Summary: Members of the winged-helix/forkhead family of transcription factors, such as FOXN4, are characterized by a 110-amino acid DNA-binding domain that can fold into a variant of the helix-turn-helix motif consisting of 3 alpha helices flanked by 2 large loops or wings. These transcription factors are involved in a variety of biologic processes as key regulators in development and metabolism (Li et al., 2004 [PubMed 15363391]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO29038 FOXN4 Knockout cell line (HEK293) Human FOXN4 1:3~1:6 Negative Online Inquiry

Background

FOXN4 Gene Knockout Cell Lines are precisely engineered cellular models that effectively delete the FOXN4 gene, which plays a crucial role in immune regulation and differentiation. These knockout cell lines utilize advanced CRISPR-Cas9 gene-editing technology to create a targeted ablation of the FOXN4 gene, allowing researchers to study its biological functions and implications in immune responses, autoimmunity, and cancer biology.

The primary function of these cell lines is to provide a platform for investigating the molecular pathways influenced by FOXN4. This is accomplished through the elimination of its expression in various cellular contexts, enabling the observation of phenotypic alterations, cell signaling changes, and transcriptional modulation that would not be possible in wild-type cells. By analyzing these changes, researchers can elucidate the role of FOXN4 in T-cell signaling, apoptosis, and inflammation.

The scientific importance of FOXN4 Gene Knockout Cell Lines lies in their potential applications across diverse research areas, including immunology, cancer research, and therapeutic development. For instance, studies utilizing these cell lines can enhance the understanding of autoimmune diseases where FOXN4 is implicated, paving the way for novel treatment strategies. Furthermore, they can facilitate drug screening assays, improving the identification of compounds targeting FOXN4-related pathways.

Compared to alternative cell models, FOXN4 Gene Knockout Cell Lines stand out due to their high specificity and reproducibility. Unlike broad-spectrum inhibitors or simple knockdown techniques, these knockout lines provide a complete loss-of-function scenario, eliminating confounding variables associated with partial inhibition. This specificity enhances data integrity, making findings more robust and reliable.

The value of FOXN4 Gene Knockout Cell Lines cannot be overstated for researchers and clinicians seeking to deepen their understanding of FOXN4's role in health and disease. With these tools, they can conduct more precise experiments, ultimately leading to breakthroughs in treatments and therapies for conditions influenced by FOXN4.

Our company specializes in providing high-quality, genetically engineered cell lines designed to meet the rigorous demands of modern research. With a commitment to scientific excellence and innovation, we empower researchers with the tools necessary to advance their studies and contribute to the field of biomedical research.

Please note that all services are for research use only. Not intended for any clinical use.

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