Gene: FERMT2
Official Full Name: FERM domain containing kindlin 2provided by HGNC
Gene Summary: Enables several functions, including phosphatidylinositol-3,4,5-trisphosphate binding activity; protein serine/threonine kinase binding activity; and type I transforming growth factor beta receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of cellular component biogenesis; and positive regulation of intracellular signal transduction. Acts upstream of or within cell adhesion and protein localization to cell junction. Located in several cellular components, including adherens junction; cytoplasmic side of plasma membrane; and focal adhesion. Biomarker of acute myeloid leukemia. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO31356 | FERMT2 Knockout cell line (HeLa) | Human | FERMT2 | 1:3~1:6 | Negative | Online Inquiry |
KO31357 | FERMT2 Knockout cell line (HCT 116) | Human | FERMT2 | 1:2~1:4 | Negative | Online Inquiry |
KO31358 | FERMT2 Knockout cell line (HEK293) | Human | FERMT2 | 1:3~1:6 | Negative | Online Inquiry |
FERMT2 Gene Knockout Cell Lines are highly specialized biological tools developed for the precise investigation of the Fermt2 gene's role in cellular processes and disease mechanisms. These genetically modified cell lines enable researchers to study the effects of gene inactivation on cellular behavior, signaling pathways, and overall physiology, making them invaluable in both basic research and therapeutic development.
The core function of these knockout cell lines is the complete elimination of the Fermt2 gene, which encodes for Fermitin Family Member 2, a protein implicated in various cellular activities such as cell adhesion, migration, and cytoskeletal organization. By utilizing CRISPR-Cas9 technology for gene editing, these cell lines provide a robust system for analyzing how the loss of Fermt2 impacts cellular functions, enabling insights into its contribution to pathologies, including cancer progression and fibrosis.
Scientifically, the FERMT2 Gene Knockout Cell Lines have significant implications in both academic and clinical research settings. They can be used to model diseases where Fermt2 is thought to play a critical role, facilitating the identification of novel therapeutic targets and potential biomarkers. Additionally, these cell lines serve as an essential resource for drug discovery, toxicology studies, and the exploration of new therapeutic strategies.
What sets our FERMT2 Gene Knockout Cell Lines apart from other genetic models is our rigorous quality control and validation processes, ensuring reproducibility and reliability in experimental results. Unlike alternatives that may not adequately replicate the gene knockout conditions or possess inconsistent phenotypes, our cell lines come with a comprehensive characterization report that guarantees their status and functionality.
For researchers and clinicians looking to deepen their understanding of Fermt2's biological functions and its implications in human health and disease, these cell lines represent a powerful resource. Our commitment to innovation in genetic engineering and our focus on providing high-quality biological products underscore our expertise in the field, ensuring that our customers receive the best tools for their research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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