Gene: FBLN5
Official Full Name: fibulin 5provided by HGNC
Gene Summary: The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3). [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO31768 | FBLN5 Knockout cell line (HeLa) | Human | FBLN5 | 1:3~1:6 | Negative | Online Inquiry |
KO31769 | FBLN5 Knockout cell line (HCT 116) | Human | FBLN5 | 1:2~1:4 | Negative | Online Inquiry |
KO31770 | FBLN5 Knockout cell line (HEK293) | Human | FBLN5 | 1:3~1:6 | Negative | Online Inquiry |
KO31771 | FBLN5 Knockout cell line (A549) | Human | FBLN5 | 1:3~1:4 | Negative | Online Inquiry |
FBLN5 Gene Knockout Cell Lines are a specialized model system designed to study the functional roles of the fibroblast growth factor-binding protein 5 (FBLN5) gene in various biological processes. These genetically modified cells have been created using CRISPR/Cas9 gene editing technology to achieve a complete knockout of FBLN5, enabling researchers to investigate the downstream effects of its loss in cellular behavior and signaling pathways.
The primary function of FBLN5 is to modulate important processes, such as cell adhesion, migration, and angiogenesis. By utilizing FBLN5 Gene Knockout Cell Lines, scientists can dissect the molecular mechanisms through which FBLN5 influences these functions, serving as a crucial tool for understanding its role in health and disease. The knockout model can facilitate investigations into disease contexts like cancer, cardiovascular disorders, and tissue repair, where FBLN5 is known to play a significant part.
The scientific importance of this product lies in its broad applications in both research and clinical settings. It can be utilized to screen for potential therapeutic targets, evaluate drug efficacy, and elucidate the pathological mechanisms underlying diseases associated with FBLN5 dysfunction. Researchers can leverage these cell lines to study cell behavior without the confounding effects of FBLN5, providing clearer insights into its biological relevance.
FBLN5 Gene Knockout Cell Lines offer distinct advantages over traditional cell models. They provide a tailored genetic framework that guarantees the absence of FBLN5, eliminating variability and enhancing reproducibility in experimental results. Additionally, researchers benefit from the ease of use and versatility in a range of assays, including cell proliferation, migration, and invasion studies.
The value of this product is further emphasized by its alignment with current trends in precision medicine, allowing researchers and clinicians to connect molecular insights with therapeutic strategies effectively. Our company brings extensive expertise in cellular models and gene editing technologies, ensuring that our FBLN5 Gene Knockout Cell Lines are of the highest quality and are supported by comprehensive technical resources. Embrace the future of biological research with our cutting-edge product, and unlock new possibilities in your investigations.
Please note that all services are for research use only. Not intended for any clinical use.
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