Gene: FADS2
Official Full Name: fatty acid desaturase 2provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO33246 | FADS2 Knockout cell line (HeLa) | Human | FADS2 | 1:3~1:6 | Negative | Online Inquiry |
KO33247 | FADS2 Knockout cell line (HCT 116) | Human | FADS2 | 1:2~1:4 | Negative | Online Inquiry |
KO33248 | FADS2 Knockout cell line (HEK293) | Human | FADS2 | 1:3~1:6 | Negative | Online Inquiry |
KO33249 | FADS2 Knockout cell line (A549) | Human | FADS2 | 1:3~1:4 | Negative | Online Inquiry |
FADS2 Gene Knockout Cell Lines are specialized cellular models engineered to silence the Fatty Acid Desaturase 2 (FADS2) gene, which plays a crucial role in the biochemical conversion of fatty acids. By specifically disrupting this gene, these cell lines allow researchers to investigate the metabolic and physiological consequences of impaired fatty acid desaturation, a process vital for maintaining cellular membrane integrity and lipid metabolism.
These knockout cell lines function through a sophisticated mechanism involving targeted gene editing techniques such as CRISPR/Cas9 or RNA interference, resulting in the complete loss of FADS2 protein function. This knockout effect provides an experimental platform to assess the resultant phenotypic changes, metabolic pathways, and the interplay between fatty acid composition and cellular signaling.
The scientific importance of FADS2 knockout cell lines lies in their application across various fields including metabolic research, oncology, and neurobiology. They serve as pivotal tools for understanding lipid metabolism disorders, inflammatory diseases, and the impact of fatty acid profile variations on health outcomes. Their use can lead to insights that inform drug development, therapeutic interventions, and nutritional science.
Compared to traditional cell lines, FADS2 Gene Knockout Cell Lines offer unique advantages, such as precise gene modification and the ability to create tailored lipid environments. This specificity enhances the validity of experimental results and reduces variability, contributing to more robust and reproducible scientific findings.
For researchers and clinicians focused on lipid metabolism and associated diseases, these knockout cell lines are invaluable for exploring novel therapeutic targets and elucidating disease mechanisms. Their comprehensive utility underscores their importance in advancing biomedical research.
Our company, with its deep expertise in gene editing technologies and commitment to providing high-quality biological products, prides itself on developing innovative tools like FADS2 Gene Knockout Cell Lines that empower the scientific community to achieve new breakthroughs.
Please note that all services are for research use only. Not intended for any clinical use.
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