Gene: F2
Official Full Name: coagulation factor II, thrombinprovided by HGNC
Gene Summary: This gene encodes the prothrombin protein (also known as coagulation factor II). This protein is proteolytically cleaved in multiple steps to form the activated serine protease thrombin. The activated thrombin enzyme plays an important role in thrombosis and hemostasis by converting fibrinogen to fibrin during blood clot formation, by stimulating platelet aggregation, and by activating additional coagulation factors. Thrombin also plays a role in cell proliferation, tissue repair, and angiogenesis as well as maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in this gene lead to various forms of thrombosis and dysprothrombinemia. Rapid increases in cytokine levels following coronavirus infections can dysregulate the coagulation cascade and produce thrombosis, compromised blood supply, and organ failure. [provided by RefSeq, May 2020]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO07712 | F2 Knockout cell line (A549) | Human | F2 | 1:3~1:4 | Negative | Online Inquiry |
F2 Gene Knockout Cell Lines are genetically engineered cellular models designed specifically to lack the functional expression of the F2 gene, which encodes for prothrombin. By utilizing advanced gene editing techniques such as CRISPR/Cas9, these cell lines provide a versatile platform for researchers to investigate the functional role of the F2 gene, its implications in coagulation pathways, and various disease mechanisms such as thrombosis and bleeding disorders.
The primary function of F2 Gene Knockout Cell Lines revolves around their ability to mimic a physiological state devoid of prothrombin, allowing for in-depth analyses of cellular responses to other coagulation factors and therapeutic interventions. This knockout model reveals the intricate interplay within the hemostatic system, facilitating studies on compensatory mechanisms in coagulation and potential targets for drug development.
In scientific research and clinical applications, these cell lines serve a pivotal role in understanding the pathophysiology of disorders related to blood coagulation, enhancing the development of novel anticoagulants or coagulation therapies. Furthermore, they are invaluable tools in pharmacological testing, enabling the screening of compounds for their efficacy and safety profiles in a controlled environment that closely mirrors human physiological conditions.
Distinct advantages of the F2 Gene Knockout Cell Lines compared to alternative models include their high fidelity to human cellular processes and reduced off-target effects due to precise gene editing techniques. These features enhance reproducibility in experimental outcomes, making them a reliable choice for time-sensitive studies.
To researchers, clinicians, and pharmaceutical developers, the value of F2 Gene Knockout Cell Lines rests in their ability to provide robust and reproducible data, ultimately informing more effective treatment strategies for clotting-related conditions.
Our company prides itself on pioneering high-quality biological products and offering unparalleled support in the scientific community, making our F2 Gene Knockout Cell Lines a trusted resource for advancing research and clinical applications in coagulation studies.
Please note that all services are for research use only. Not intended for any clinical use.
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