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EFEMP2 Knockout Cell Lines

Gene: EFEMP2

Official Full Name: EGF containing fibulin extracellular matrix protein 2provided by HGNC

Gene Summary: A large number of extracellular matrix proteins have been found to contain variations of the epidermal growth factor (EGF) domain and have been implicated in functions as diverse as blood coagulation, activation of complement and determination of cell fate during development. The protein encoded by this gene contains four EGF2 domains and six calcium-binding EGF2 domains. This gene is necessary for elastic fiber formation and connective tissue development. Defects in this gene are cause of an autosomal recessive cutis laxa syndrome. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jan 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO26824 EFEMP2 Knockout cell line (HeLa) Human EFEMP2 1:3~1:6 Negative Online Inquiry
KO26825 EFEMP2 Knockout cell line (HCT 116) Human EFEMP2 1:2~1:4 Negative Online Inquiry

Background

EFEMP2 Gene Knockout Cell Lines are genetically engineered cell cultures that have had the EFEMP2 gene, known to play a crucial role in various cellular processes including cell adhesion, proliferation, and tissue homeostasis, inactivated or "knocked out." This approach allows researchers to investigate the gene’s specific contributions to biological pathways and disease mechanisms, particularly those involving connective tissue disorders and cancers.

These knockout cell lines function by utilizing CRISPR/Cas9 or other gene-editing technologies to precisely disable the EFEMP2 gene. By eliminating this gene, the resultant cell lines provide a valuable model for studying the direct effects of EFEMP2 loss on cellular behavior, signaling pathways, and interactions within the extracellular matrix. This experimental framework enables researchers to elucidate the biological functions of EFEMP2 and test therapeutic approaches aimed at mitigating its associated pathological conditions.

The scientific significance of EFEMP2 Gene Knockout Cell Lines lies in their broad applications in both fundamental and translational research. They facilitate investigations into the roles of EFEMP2 in diseases, enabling the development of targeted therapies and novel biomolecular approaches. Furthermore, these cell lines are indispensable tools in pharmacological studies, allowing for the screening of drug efficacy and safety profiles in an environment that closely mimics pathological states.

What sets our EFEMP2 Gene Knockout Cell Lines apart from alternatives is the rigorous validation process we apply. Each cell line undergoes extensive characterizations, ensuring consistent genetic modification and performance. They are also accompanied by comprehensive documentation and support, allowing for seamless integration into ongoing research projects.

For researchers and clinicians, the value of these cell lines extends beyond their ability to model EFEMP2-associated conditions; they represent a significant advancement in understanding complex biological interactions. Our product supports the scientific community in uncovering new therapeutic avenues, ultimately leading to improved patient outcomes.

With a robust background in biotechnological innovations, our company prides itself on providing high-quality biological products designed to support cutting-edge research and clinical applications. Our commitment to excellence enables researchers to trust in the quality and reliability of our EFEMP2 Gene Knockout Cell Lines.

Please note that all services are for research use only. Not intended for any clinical use.

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