Gene: DST
Official Full Name: dystoninprovided by HGNC
Gene Summary: This gene encodes a member of the plakin protein family of adhesion junction plaque proteins. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of some variants has not been defined. It has been reported that some isoforms are expressed in neural and muscle tissue, anchoring neural intermediate filaments to the actin cytoskeleton, and some isoforms are expressed in epithelial tissue, anchoring keratin-containing intermediate filaments to hemidesmosomes. Consistent with the expression, mice defective for this gene show skin blistering and neurodegeneration. [provided by RefSeq, Mar 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38777 | DST Knockout cell line (HeLa) | Human | DST | 1:3~1:6 | Negative | Online Inquiry |
KO38778 | DST Knockout cell line (HCT 116) | Human | DST | 1:2~1:4 | Negative | Online Inquiry |
KO38779 | DST Knockout cell line (HEK293) | Human | DST | 1:3~1:6 | Negative | Online Inquiry |
KO38780 | DST Knockout cell line (A549) | Human | DST | 1:3~1:4 | Negative | Online Inquiry |
DST Gene Knockout Cell Lines are genetically engineered cell lines in which the DST gene, responsible for producing the dystonin protein, has been effectively disrupted or "knocked out." This innovative biological product allows researchers to study the roles of the DST gene in cellular and molecular mechanisms, particularly in the context of various diseases and physiological processes. By utilizing advanced CRISPR-Cas9 gene-editing technologies, these cell lines exhibit a complete lack of dystonin expression, providing a powerful tool for investigating the gene's contributions to cellular function and pathology.
The primary function of the DST gene knockout is to facilitate an in-depth understanding of the repercussions of dystonin absence on cellular structures, signaling pathways, and interactions that may lead to disease states. In particular, studying these cell lines can unveil insights into neurodegenerative disorders and other conditions where structural stability and cellular integrity are compromised. Scientists can utilize these models to elucidate underlying mechanisms of diseases such as dystonia, epidermolysis bullosa, and certain forms of muscular dystrophy.
The value of DST Gene Knockout Cell Lines in research and clinical applications is underscored by their ability to mimic disease conditions, serving as vital models for drug discovery and development. They are particularly advantageous compared to conventional wild-type cell lines as they eliminate the confounding effects of the DST gene's expression, leading to more accurate data and findings. Furthermore, these knockout models enable the testing of therapeutic interventions that target pathways disrupted due to dystonin deficiency, potentially paving the way for novel treatment strategies.
Researchers and clinicians will find great utility in DST Gene Knockout Cell Lines due to their specificity and the depth of biological insights they can provide. These cell lines can aid in the identification of genetic compensatory mechanisms, enhancing understanding of gene functions and providing data critical for advancing knowledge in fields such as genetics, cell biology, and regenerative medicine.
Our company specializes in delivering high-quality biological products and cell line models with a commitment to supporting innovative research. With rigorous quality control and verification protocols, we ensure that our DST Gene Knockout Cell Lines meet the highest standards, empowering the scientific community to make groundbreaking discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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