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DLG5 Knockout Cell Lines

Gene: DLG5

Official Full Name: discs large MAGUK scaffold protein 5provided by HGNC

Gene Summary: This gene encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure. Alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08532 DLG5 Knockout cell line (HeLa) Human DLG5 1:3~1:6 Negative Online Inquiry
KO08533 DLG5 Knockout cell line (HCT 116) Human DLG5 1:2~1:4 Negative Online Inquiry
KO08534 DLG5 Knockout cell line (HEK293) Human DLG5 1:3~1:6 Negative Online Inquiry
KO08535 DLG5 Knockout cell line (A549) Human DLG5 1:3~1:4 Negative Online Inquiry

Background

DLG5 Gene Knockout Cell Lines are meticulously engineered cellular models designed to facilitate in-depth studies of the DLG5 gene, which encodes for a membrane-associated guanylate kinase (MAGUK) protein involved in signaling pathways and cellular interactions. These knockout cell lines enable researchers to investigate the phenotypic consequences of the absence of DLG5, thus providing valuable insights into its role in cellular functions such as synaptic transmission and development, as well as its implications in various diseases.

The primary function of these knockout cell lines lies in their capability to eliminate DLG5 expression, thereby revealing the downstream effects on cellular signaling and mechanical properties. Researchers employ techniques such as CRISPR-Cas9 gene editing to achieve precise gene knockout, allowing for the exploration of how the loss of DLG5 affects targeted pathways, cellular architecture, and even cell viability. This capacity to manipulate gene expression is invaluable in elucidating the gene's functional roles and its involvement in pathologies, particularly in neurodegenerative diseases and cancer.

In scientific research and clinical settings, DLG5 Gene Knockout Cell Lines hold significant importance as tools for validating the function of DLG5 in cell signaling, understanding disease mechanisms, and screening potential therapeutic interventions. They provide a robust platform for drug discovery and development, helping to generate data that could lead to innovations in treatment strategies.

What sets DLG5 Gene Knockout Cell Lines apart from other cellular models is their precision in mimicking genetic conditions while maintaining physiological relevance. Compared to alternative models that may not fully recapitulate the complexity of gene function in vivo, these knockout lines allow for a highly controlled environment, ensuring reproducible results that enhance the reliability of experimental findings.

For researchers, clinicians, and pharmaceutical companies aiming to deepen their understanding of genetic regulation and its therapeutic implications, DLG5 Gene Knockout Cell Lines offer a unique and powerful resource. Our company is dedicated to providing high-quality biological products backed by extensive expertise in gene editing technologies, enabling innovative research and paving the way for breakthroughs in healthcare.

Please note that all services are for research use only. Not intended for any clinical use.

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