Gene: DBN1
Official Full Name: drebrin 1provided by HGNC
Gene Summary: The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38292 | DBN1 Knockout cell line (HeLa) | Human | DBN1 | 1:3~1:6 | Negative | Online Inquiry |
KO38293 | DBN1 Knockout cell line (HCT 116) | Human | DBN1 | 1:2~1:4 | Negative | Online Inquiry |
KO38294 | DBN1 Knockout cell line (HEK293) | Human | DBN1 | 1:3~1:6 | Negative | Online Inquiry |
KO38295 | DBN1 Knockout cell line (A549) | Human | DBN1 | 1:3~1:4 | Negative | Online Inquiry |
DBN1 Gene Knockout Cell Lines represent a significant advancement in molecular biology, specifically engineered to delete the DBN1 gene, which encodes the protein drebrin. Drebrin is implicated in various cellular processes including cytoskeletal dynamics, cell signaling, and synaptic function, making the DBN1 knockout a vital tool for investigating the role of this protein in health and disease. These cell lines allow researchers to explore the consequences of DBN1 loss, providing a platform to study its effects on neuronal development, plasticity, and disorders such as Alzheimer's disease and other neurodegenerative conditions.
The key function of the DBN1 knockout cell lines lies in their ability to facilitate the dissection of the specific pathways and mechanisms influenced by the absence of drebrin. By observing the phenotypic changes and molecular alterations that occur in these knockout cells, researchers can elucidate the roles of DBN1 in synaptic structure and function. Furthermore, the cell lines can be utilized in drug discovery assays, toxicology studies, and functional genomics, thereby broadening their application in both basic and applied research.
The scientific importance of these cell lines is underscored by their versatility, which allows for targeted investigations into neurobiological processes. Compared to conventional cell lines that express the DBN1 gene, our knockout models provide unique insights into the gene's specific functions without confounding variables, ultimately enhancing the specificity of experimental outcomes. This specificity also distinguishes our offering from alternative products, ensuring that researchers obtain high-quality data that reliably reflects the biological implications of DBN1 deletion.
For researchers and clinicians focused on understanding the complexities of neural function and pathology, DBN1 Gene Knockout Cell Lines are an invaluable resource. They not only streamline experimental design but also foster the generation of high-impact publications that can advance the field of neurobiology.
Our company, with a robust background in genetic engineering and cellular biology, is dedicated to providing innovative tools for life sciences research. We take pride in the quality and reliability of our products, ensuring that each cell line meets rigorous standards for scientific research.
Please note that all services are for research use only. Not intended for any clinical use.
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