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CYP4F12 Knockout Cell Lines

Gene: CYP4F12

Official Full Name: cytochrome P450 family 4 subfamily F member 12provided by HGNC

Gene Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme is capable of oxdizing arachidonic acid. It can also catalyze the epoxidation of 22:6n-3 and 22:5n-3 polyunsaturated long-chain fatty acids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO18447 CYP4F12 Knockout cell line (HeLa) Human CYP4F12 1:3~1:6 Negative Online Inquiry
KO18448 CYP4F12 Knockout cell line (HCT 116) Human CYP4F12 1:2~1:4 Negative Online Inquiry
KO18449 CYP4F12 Knockout cell line (A549) Human CYP4F12 1:3~1:4 Negative Online Inquiry

Background

CYP4F12 Gene Knockout Cell Lines are genetically modified cellular models designed to explore the biological functions and pharmacological implications of the CYP4F12 gene, which is part of the cytochrome P450 superfamily of enzymes. This gene plays a crucial role in the metabolism of various lipid mediators, including eicosanoids, which are involved in numerous physiological processes such as inflammation and homeostasis. By knocking out the CYP4F12 gene, researchers can study the effects of its absence on cellular behavior and metabolic pathways, thereby providing insights into its role in health and disease.

These knockout cell lines provide a powerful tool for investigating the mechanistic pathways regulated by CYP4F12. Through the deletion of this specific gene, scientists can observe changes in key functions such as the metabolism of fatty acids, the modulation of inflammatory responses, and the cellular effects on lipid signaling pathways. The ability to create a controlled environment for studying these processes is invaluable for both fundamental and applied research.

Scientific studies using CYP4F12 knockout models can enhance our understanding of various clinical conditions, such as cardiovascular diseases and metabolic syndromes, where lipid metabolism is significantly altered. Moreover, these cell lines serve as a critical resource in drug discovery and development, allowing researchers to evaluate the pharmacokinetics and toxicity of new therapeutic agents in a biologically relevant context.

One of the unique advantages of CYP4F12 Gene Knockout Cell Lines over alternative methods is the precision in gene editing, which facilitates specific and reproducible experimentation. Unlike other models that may exhibit variable expression or unintended genetic alterations, these knockout lines ensure consistency and reliability, ultimately leading to more robust scientific findings.

By leveraging the value of CYP4F12 Gene Knockout Cell Lines, researchers can obtain deeper insights into the biochemical and clinical relevance of the CYP4F12 enzyme, directly contributing to advancements in therapeutic strategies. With our commitment to excellence in genetic engineering and cell line development, our company provides high-quality products that empower researchers and clinicians to achieve their scientific goals effectively.

Please note that all services are for research use only. Not intended for any clinical use.

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