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CLIP2 Knockout Cell Lines

Gene: CLIP2

Official Full Name: CAP-Gly domain containing linker protein 2provided by HGNC

Gene Summary: The protein encoded by this gene belongs to the family of cytoplasmic linker proteins, which have been proposed to mediate the interaction between specific membranous organelles and microtubules. This protein was found to associate with both microtubules and an organelle called the dendritic lamellar body. This gene is hemizygously deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01938 CLIP2 Knockout cell line (HeLa) Human CLIP2 1:3~1:6 Negative Online Inquiry
KO01939 CLIP2 Knockout cell line (HCT 116) Human CLIP2 1:2~1:4 Negative Online Inquiry
KO01940 CLIP2 Knockout cell line (HEK293) Human CLIP2 1:3~1:6 Negative Online Inquiry
KO01941 CLIP2 Knockout cell line (A549) Human CLIP2 1:3~1:4 Negative Online Inquiry

Background

CLIP2 Gene Knockout Cell Lines are genetically engineered cell lines designed for the precise study of the CLIP2 gene, a key player in cellular processes including synaptic function and neuronal signaling. These knockout cell lines have been developed using advanced gene-editing techniques, such as CRISPR-Cas9, to create a robust model system that allows researchers to explore the molecular foundations of CLIP2 function and its implications in neurological disorders.

The primary mechanism of these knockout cell lines involves the targeted disruption of the CLIP2 gene, leading to the absence of CLIP2 protein expression. This enables functional assays to discern the gene's role in cellular pathways, evaluating phenotypic changes in neuronal communication and establishing connections to conditions like autism spectrum disorders and schizophrenia. By utilizing these cell lines, researchers can dissect the signaling pathways affected by the loss of CLIP2, deepening our understanding of synaptic plasticity and its relevance in both normal physiology and disease states.

The scientific significance of CLIP2 Gene Knockout Cell Lines extends to various applications within both basic research and therapeutic development. These models allow for the validation of drug targets, assessments of gene function, and screening for potential therapies in relevant neurological contexts. Compared to traditional methods of studying gene function—such as knockdown approaches which can yield incomplete or transient effects—our knockout lines offer a stable and complete loss-of-function model, providing more reliable and reproducible results.

Researchers and clinicians alike will find value in these cell lines due to their specificity and robustness, driving forward discoveries that could translate into real-world therapeutic strategies. The capability to manipulate and study the CLIP2 gene in a controlled environment empowers users with the tools necessary to advance their research agendas without the confounding variables often associated with alternative models.

Our company prides itself on its commitment to delivering high-quality biological products tailored for cutting-edge research, backed by expertise in genetic engineering and cellular biology. With CLIP2 Gene Knockout Cell Lines, investors and researchers can expect not only superior products but also comprehensive support in their quest to innovate and uncover breakthroughs in science.

Please note that all services are for research use only. Not intended for any clinical use.

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