Gene: CEP350
Official Full Name: centrosomal protein 350provided by HGNC
Gene Summary: The product of this gene is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins. The encoded protein primarily localizes to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. The encoded protein directly interacts with another large centrosomal protein and is required to anchor microtubules at the centrosome. It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32634 | CEP350 Knockout cell line (HeLa) | Human | CEP350 | 1:3~1:6 | Negative | Online Inquiry |
KO32635 | CEP350 Knockout cell line (HCT 116) | Human | CEP350 | 1:2~1:4 | Negative | Online Inquiry |
KO32636 | CEP350 Knockout cell line (HEK293) | Human | CEP350 | 1:3~1:6 | Negative | Online Inquiry |
KO32637 | CEP350 Knockout cell line (A549) | Human | CEP350 | 1:3~1:4 | Negative | Online Inquiry |
CEP350 Gene Knockout Cell Lines are engineered cellular models that have undergone precise genetic modifications to eliminate the expression of the CEP350 gene. This gene is critical in the assembly and maintenance of centrosomes, and its knockout allows for the study of various cellular processes, including cell division and signaling pathways that are crucial in both normal physiological functions and disease states. By utilizing techniques such as CRISPR-Cas9 gene editing, these cell lines serve as vital tools for scientists aiming to dissect the role of CEP350 in various biological contexts.
The key function of CEP350 Gene Knockout Cell Lines lies in their ability to mimic human disease models, particularly in cancer and developmental biology. By observing the phenotypic outcomes of CEP350 disruption, researchers can explore the implications of centrosome abnormalities that often lead to aneuploidy and tumorigenesis. This functional analysis enables insightful investigations into the molecular mechanisms by which CEP350 contributes to cellular homeostasis and pathophysiology.
The scientific importance of these cell lines cannot be overstated, as they facilitate high-throughput screening for therapeutic targets and serve as platforms for drug development in oncology. By providing a unique perspective on the roles of centrosomal components, these cell lines hold promise for elucidating novel pathways in disease progression and treatment resistance.
Compared to traditional models, the CEP350 Gene Knockout Cell Lines offer distinct advantages, including the elimination of gene expression with high specificity and minimal off-target effects. This precision leads to more reliable and reproducible experimental results, which are essential for advancing research in a competitive landscape. Additionally, they are readily adaptable for various downstream applications, including gene expression analyses, proteomics, and cellular interaction studies.
Researchers and clinicians alike will find immense value in CEP350 Gene Knockout Cell Lines as they enable deeper insights into centrosome-related diseases and therapies. The ability to manipulate these cell lines for specific experiments positions them as a key resource in the field of molecular biology and genetics.
Our company specializes in providing high-quality biological products, including expertly crafted gene knockout models that meet the rigorous demands of modern research and clinical applications. With a commitment to scientific excellence and innovation, we support our customers in driving advancements that improve understanding and treatment of complex diseases.
Please note that all services are for research use only. Not intended for any clinical use.
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