Gene: CBX4
Official Full Name: chromobox 4provided by HGNC
Gene Summary: Enables SUMO binding activity; SUMO ligase activity; and enzyme binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nuclear body. Part of PRC1 complex. Implicated in hepatocellular carcinoma. Biomarker of hepatocellular carcinoma. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05084 | CBX4 Knockout cell line (HeLa) | Human | CBX4 | 1:3~1:6 | Negative | Online Inquiry |
KO05085 | CBX4 Knockout cell line (HCT 116) | Human | CBX4 | 1:2~1:4 | Negative | Online Inquiry |
KO05086 | CBX4 Knockout cell line (HEK293) | Human | CBX4 | 1:3~1:6 | Negative | Online Inquiry |
KO05087 | CBX4 Knockout cell line (A549) | Human | CBX4 | 1:3~1:4 | Negative | Online Inquiry |
CBX4 Gene Knockout Cell Lines are precisely engineered cellular models designed to facilitate the study of CBX4 gene functions and its role in cellular processes. CBX4, a member of the chromobox family of proteins, has been implicated in various biological processes, including gene regulation, chromatin remodeling, and cellular response to stress. These knockout cell lines enable researchers to investigate the phenotypic consequences of CBX4 loss, thus providing insights into its contributions to cancer progression, cellular differentiation, and epigenetic regulation.
The key mechanism behind CBX4 Gene Knockout Cell Lines lies in CRISPR-Cas9 technology, which allows for the targeted disruption of the CBX4 gene. Following its inactivation, researchers can observe changes in gene expression, protein interactions, and alterations in cellular behavior, thus providing a robust platform for elucidating the downstream effects of eliminating CBX4. This is particularly advantageous for studies focusing on the epigenetic landscape of cancer biology, where the role of chromatin modifiers like CBX4 is critical.
Scientifically, these knockout cell lines hold immense importance in both research and clinical contexts. They serve as valuable tools for screening potential therapeutic compounds that target CBX4-related pathways and contribute to understanding mechanisms of drug resistance or tumorigenesis. Furthermore, they enable the development of gene therapy approaches aimed at restoring normal function in cases where CBX4 is aberrantly expressed.
The advantages of using CBX4 Gene Knockout Cell Lines over traditional models include their precise genetic modification, which minimizes off-target effects, and their reproducible behavior, ensuring reliable experimental outcomes. This precision allows researchers to draw more accurate conclusions about the biological roles of CBX4, reinforcing its relevance in novel therapeutic strategies.
For researchers and clinicians, the value of these cell lines extends beyond mere convenience; they offer a definitive pathway to unlock new avenues of research and treatment. With our commitment to quality and innovation, our company specializes in producing high-fidelity biological products, and our expertise in gene editing and cellular model development ensures that our CBX4 Gene Knockout Cell Lines meet the rigorous standards required for cutting-edge research.
Please note that all services are for research use only. Not intended for any clinical use.
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