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AGER Knockout Cell Lines

Gene: AGER

Official Full Name: advanced glycosylation end-product specific receptorprovided by HGNC

Gene Summary: The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO09387 AGER Knockout cell line (HeLa) Human AGER 1:3~1:6 Negative Online Inquiry
KO09388 AGER Knockout cell line (HCT 116) Human AGER 1:2~1:4 Negative Online Inquiry
KO09389 AGER Knockout cell line (HEK293) Human AGER 1:3~1:6 Negative Online Inquiry
KO09390 AGER Knockout cell line (A549) Human AGER 1:3~1:4 Negative Online Inquiry

Background

AGER Gene Knockout Cell Lines are specifically engineered cellular models in which the Advanced Glycation End-product Receptor (AGER) gene has been deliberately disrupted, creating a powerful tool for researchers exploring the role of AGER in various physiological and pathological processes. These knockout cell lines serve to elucidate the molecular mechanisms by which AGER influences cellular functions, such as inflammation, oxidative stress response, and the progression of age-related diseases.

The functionality of AGER Gene Knockout Cell Lines is built upon the principle of gene editing, utilizing cutting-edge CRISPR/Cas9 technology to ensure precise targeting and elimination of the AGER gene. By studying these cells, researchers can investigate the receptor's impact on signal transduction pathways and its interactions with advanced glycation end-products, thereby offering insights into diseases like diabetes, cardiovascular disorders, and neurodegenerative conditions.

Scientifically, AGER Gene Knockout Cell Lines hold significant value in both research and clinical settings. They enable scientists to dissect biological pathways involving AGER while providing a platform to test new therapeutic interventions aimed at modulating receptor activity. This versatility makes them indispensable for modeling disease states and developing targeted treatments.

Compared to alternative models, these knockout cell lines offer higher specificity and relevance to human disease. Traditional techniques may rely on overexpressed models or animal studies, which often fail to fully reflect human pathophysiology. AGER Gene Knockout Cell Lines provide a more direct approach, delivering reliable and reproducible results that enhance the quality of scientific investigation.

For researchers and clinicians invested in advancing their understanding of AGER's biological roles, these knockout cell lines represent a valuable asset, facilitating breakthroughs in therapeutic strategies and enhancing patient care. Our company prides itself on integrating innovative gene-editing technologies with extensive expertise in cellular biology, making our AGER Gene Knockout Cell Lines a leading choice for forward-thinking research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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