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AGAP3 Knockout Cell Lines

Gene: AGAP3

Official Full Name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 3provided by HGNC

Gene Summary: This gene encodes an essential component of the N-methyl-D-aspartate (NMDA) receptor signaling complex which mediates long-term potentiation in synapses by linking activation of NMDA receptor to alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking. The encoded protein contains an N-terminal GTPase-like domain, a pleckstrin homology domain, an ArfGAP domain and several C-terminal ankryn repeat domains. [provided by RefSeq, Apr 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO30463 AGAP3 Knockout cell line (HeLa) Human AGAP3 1:3~1:6 Negative Online Inquiry
KO30464 AGAP3 Knockout cell line (HCT 116) Human AGAP3 1:2~1:4 Negative Online Inquiry
KO30465 AGAP3 Knockout cell line (HEK293) Human AGAP3 1:3~1:6 Negative Online Inquiry
KO30466 AGAP3 Knockout cell line (A549) Human AGAP3 1:3~1:4 Negative Online Inquiry

Background

AGAP3 Gene Knockout Cell Lines are genetically engineered cell lines designed to specifically inhibit the expression of the AGAP3 gene, known for its regulatory role in cellular processes such as endocytosis, cell signaling, and proliferation. By utilizing advanced CRISPR/Cas9 technology, these knockout cell lines provide a robust platform for studying the functional implications of AGAP3 in various biological contexts. The mechanism of action involves creating specific double-strand breaks in the AGAP3 gene, leading to insertions or deletions that disrupt the coding sequence, effectively silencing the gene's expression.

The scientific significance of AGAP3 Gene Knockout Cell Lines lies in their potential applications across both research and clinical settings. Researchers studying cancer biology, neurodevelopmental disorders, and cellular signaling pathways can leverage these cell lines to explore how AGAP3 dysregulation contributes to disease states. Furthermore, the versatility of these cell lines allows for the evaluation of pharmacological compounds targeting pathways influenced by AGAP3, paving the way for novel therapeutic strategies.

What sets AGAP3 Gene Knockout Cell Lines apart from conventional models is their specificity and reliability in gene silencing, offering more precise insights into the gene's role. Unlike traditional methods that may have off-target effects or incomplete knockdown, our cell lines guarantee consistent results, thus enhancing the reproducibility of research findings. Additionally, these cell lines are readily available in multiple backgrounds, allowing users to select the most relevant model for their studies.

The valuable insights gained from using AGAP3 Gene Knockout Cell Lines can accelerate the discovery of new biomarkers and treatment options, making them indispensable tools for researchers and clinicians alike. Our commitment to cutting-edge biotechnology and stringent quality controls ensures that our products are of the highest standards, empowering your research and enhancing your capabilities in investigating gene functions and their implications in health and disease.

Please note that all services are for research use only. Not intended for any clinical use.

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