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RCAN1 Knockout Cell Lines

Gene: RCAN1

Official Full Name: regulator of calcineurin 1provided by HGNC

Gene Summary: The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38162 RCAN1 Knockout cell line (HeLa) Human RCAN1 1:3~1:6 Negative Online Inquiry
KO38163 RCAN1 Knockout cell line (HCT 116) Human RCAN1 1:2~1:4 Negative Online Inquiry
KO38164 RCAN1 Knockout cell line (HEK293) Human RCAN1 1:3~1:6 Negative Online Inquiry
KO38165 RCAN1 Knockout cell line (A549) Human RCAN1 1:3~1:4 Negative Online Inquiry

Background

RCAN1 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to facilitate the study of the regulatory protein RCAN1 (Regulator of Calcineurin 1). These cell lines have had the RCAN1 gene selectively disrupted, allowing researchers to investigate the downstream effects of RCAN1 loss on cellular pathways, especially those related to calcium signaling and immune responses. The functionality of these knockout cell lines offers a robust model to examine the role of RCAN1 in various physiological and pathological contexts, thereby enhancing our understanding of neuromuscular disorders, cardiovascular diseases, and stress responses.

Key mechanisms by which RCAN1 influences cellular behavior include its role in modulating calcineurin activity, which is critical for calcium-dependent signal transduction. By utilizing RCAN1 Gene Knockout Cell Lines, researchers can delineate the specific pathways affected by the absence of this protein, thus unveiling new therapeutic targets for disease intervention.

The scientific importance of these cell lines extends into diverse research fields, including cardiovascular health and neurobiology. In clinical settings, insights gained from studying RCAN1 can lead to biomarkers for disease progression or strategies for intervention in calcineurin-related conditions.

Compared to traditional models, the RCAN1 Gene Knockout Cell Lines provide a uniquely clean genetic background, devoid of confounding influences that might arise from partial gene expression or polymorphisms. This specificity enhances the reliability of experimental outcomes, making them invaluable tools for both academic research and pharmaceutical development.

For researchers and clinicians, the value of the RCAN1 Gene Knockout Cell Lines lies in their ability to unlock novel molecular mechanisms and validate new therapeutic strategies. These tools empower scientists to contribute to significant advancements in understanding complex biological systems.

Our company is dedicated to providing high-quality biological tools that empower research and facilitate innovation. With a strong commitment to excellence and support, we ensure that our products meet the rigorous standards necessary for cutting-edge scientific investigation.

Please note that all services are for research use only. Not intended for any clinical use.

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