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HSPB1 Knockout Cell Lines

Gene: HSPB1

Official Full Name: heat shock protein family B (small) member 1provided by HGNC

Gene Summary: This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. [provided by RefSeq, Aug 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00562 HSPB1 Knockout cell line (HCT 116) Human HSPB1 1:2~1:4 Negative Online Inquiry
KO10748 HSPB1 Knockout cell line (HeLa) Human HSPB1 1:3~1:6 Negative Online Inquiry
KO10749 HSPB1 Knockout cell line (HEK293) Human HSPB1 1:3~1:6 Negative Online Inquiry
KO10750 HSPB1 Knockout cell line (A549) Human HSPB1 1:3~1:4 Negative Online Inquiry

Background

HSPB1 Gene Knockout Cell Lines are sophisticated biological tools developed to facilitate the study of the HSPB1 gene, which encodes heat shock protein beta-1, a crucial component involved in cellular stress responses and protein homeostasis. These engineered cell lines possess a targeted deletion of the HSPB1 gene, enabling researchers to investigate the specific role and function of this protein under various physiological and pathological conditions.

The primary function of HSPB1 revolves around its ability to protect cells from stress-induced damage through mechanisms such as inhibition of apoptosis, prevention of protein aggregation, and modulation of cellular signaling pathways. By utilizing HSPB1 Gene Knockout Cell Lines, researchers gain insight into the molecular mechanisms linked to diseases associated with cellular stress responses, including neurodegenerative diseases, cancer, and metabolic disorders.

Scientifically, these knockout models are invaluable in both research and clinical settings. They allow for the dissection of pathways where HSPB1 plays a critical role, facilitating the identification of therapeutic targets and biomarkers. Their application can lead to pioneering discoveries in understanding disease mechanisms and potentially developing novel treatment strategies.

Distinctively, HSPB1 Gene Knockout Cell Lines offer several advantages over traditional cell lines. They provide a clean genetic background devoid of HSPB1 expression, which helps eliminate confounding variables that may arise from the presence of functional gene product. Additionally, these lines can be utilized with various experimental setups, including high-throughput screening and gene editing, enabling flexibility and adaptability in research designs.

For researchers and clinicians seeking to deepen their understanding of stress response mechanisms in human health and disease, our HSPB1 Gene Knockout Cell Lines are an indispensable tool. They provide a robust platform for cutting-edge research, paving the way for advancements in therapeutic development. As a company with extensive expertise in genetic engineering and biological research products, we are committed to supporting the scientific community with high-quality, reliable solutions that cater to the evolving needs of modern biology.

Please note that all services are for research use only. Not intended for any clinical use.

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