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HSD3B7 Knockout Cell Lines

Gene: HSD3B7

Official Full Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7provided by HGNC

Gene Summary: This gene encodes an enzyme which is involved in the initial stages of the synthesis of bile acids from cholesterol and a member of the short-chain dehydrogenase/reductase superfamily. The encoded protein is a membrane-associated endoplasmic reticulum protein which is active against 7-alpha hydrosylated sterol substrates. Mutations in this gene are associated with a congenital bile acid synthesis defect which leads to neonatal cholestasis, a form of progressive liver disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04859 HSD3B7 Knockout cell line (HeLa) Human HSD3B7 1:3~1:6 Negative Online Inquiry
KO04860 HSD3B7 Knockout cell line (HCT 116) Human HSD3B7 1:2~1:4 Negative Online Inquiry
KO04861 HSD3B7 Knockout cell line (HEK293) Human HSD3B7 1:3~1:6 Negative Online Inquiry
KO04862 HSD3B7 Knockout cell line (A549) Human HSD3B7 1:3~1:4 Negative Online Inquiry

Background

HSD3B7 Gene Knockout Cell Lines are specially engineered cell models designed to facilitate the study of the HSD3B7 gene, which encodes an enzyme crucial in the conversion of steroid precursors to active steroid hormones. These knockout cell lines are generated using advanced gene-editing technologies, such as CRISPR-Cas9, which precisely disrupt the expression of the HSD3B7 gene. The absence of this gene allows researchers to investigate its role in various biological processes, particularly in steroidogenesis, and to understand its implications in related diseases, thereby paving the way for targeted therapeutic strategies.

The unique functionality of these knockout cell lines lies in their capacity to serve as a controlled system to evaluate the effects of HSD3B7 deficiency on metabolic pathways, cellular signaling, and hormonal regulation. By studying the knockout variants alongside wild-type controls, researchers can gain insights into the gene's contributions to metabolic disorders, reproductive health, and adrenal function. These models are invaluable in drug discovery processes, enabling the screening of potential therapeutics aimed at modulating steroidogenesis.

The scientific importance of HSD3B7 Gene Knockout Cell Lines in both research and clinical settings is profound. They offer a straightforward method to probe the mechanisms of steroid hormone production and the pathophysiology of diseases like congenital adrenal hyperplasia and certain cancers. Compared to traditional cell models, these specialized knockout lines provide a higher degree of specificity and reliability, reducing the likelihood of confounding variables in experimental outcomes.

For researchers and clinicians, the primary advantages of utilizing HSD3B7 Gene Knockout Cell Lines are their capacity for reproducibility and the depth of insight they offer into gene function and related biological controls. By leveraging these cell lines, users can accelerate the transition from laboratory findings to clinical applications, ultimately contributing to advancements in personalized medicine and targeted therapies.

Our company is committed to supporting the scientific community with high-quality, precise biological products like HSD3B7 Gene Knockout Cell Lines. Leveraging extensive expertise and a robust platform in gene editing and cell line development, we ensure that researchers have the tools they need to push the boundaries of their work effectively and ethically.

Please note that all services are for research use only. Not intended for any clinical use.

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