Gene: DYRK3
Official Full Name: dual specificity tyrosine phosphorylation regulated kinase 3provided by HGNC
Gene Summary: This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO06265 | DYRK3 Knockout cell line (HeLa) | Human | DYRK3 | 1:3~1:6 | Negative | Online Inquiry |
KO06266 | DYRK3 Knockout cell line (HCT 116) | Human | DYRK3 | 1:2~1:4 | Negative | Online Inquiry |
KO06267 | DYRK3 Knockout cell line (HEK293) | Human | DYRK3 | 1:3~1:6 | Negative | Online Inquiry |
KO06268 | DYRK3 Knockout cell line (A549) | Human | DYRK3 | 1:3~1:4 | Negative | Online Inquiry |
DYRK3 Gene Knockout Cell Lines represent a cutting-edge tool in genetic research and functional genomics, specifically designed to investigate the role of the dual specificity tyrosine-phosphorylation-regulated kinase 3 (DYRK3) gene in cellular processes. These cell lines are engineered to have a complete loss-of-function of the DYRK3 gene, enabling scientists to study its contributions to signal transduction, cell proliferation, and differentiation without the confounding effects of its normal expression.
The primary mechanism of action involves the elimination of DYRK3, a serine/threonine kinase that plays a critical role in various cellular pathways, including those involved in stress response and neurodevelopment. By creating a cell line where DYRK3 is non-functional, researchers can more easily dissect the downstream effects on cellular signaling pathways and understand the broader implications of DYRK3 activity in health and disease contexts.
The scientific importance of DYRK3 Gene Knockout Cell Lines extends to both academic research and clinical settings, where these tools can elucidate the molecular underpinnings of neurodegenerative diseases, cancer, and metabolic disorders. Their use can drive forward therapeutic strategies aimed at modulating DYRK3 activity, paving the way for innovative treatments targeting these conditions.
What sets these cell lines apart from traditional genetic models is their reliability and specificity. Researchers benefit from a more consistent experimental environment, leading to reproducible results, which is crucial for advancing scientific understanding. Additionally, the ready availability of these knockout lines reduces the time and resources typically required to generate similar models from scratch.
For researchers and clinicians, the value of DYRK3 Gene Knockout Cell Lines lies in their potential to accelerate discoveries in the field of genetics and personalized medicine. With comprehensive technical support and a commitment to quality, our company excels in providing high-performing biological products that empower researchers to advance their work effectively and efficiently.
Please note that all services are for research use only. Not intended for any clinical use.
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