Gene: ZNF444
Official Full Name: zinc finger protein 444provided by HGNC
Gene Summary: This gene encodes a zinc finger protein which activates transcription of a scavenger receptor gene involved in the degradation of acetylated low density lipoprotein (Ac-LDL) (PMID: 11978792). This gene is located in a cluster of zinc finger genes on chromosome 19 at q13.4. A pseudogene of this gene is located on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO12227 | ZNF444 Knockout cell line (HeLa) | Human | ZNF444 | 1:3~1:6 | Negative | Online Inquiry |
KO12228 | ZNF444 Knockout cell line (HCT 116) | Human | ZNF444 | 1:2~1:4 | Negative | Online Inquiry |
KO12229 | ZNF444 Knockout cell line (HEK293) | Human | ZNF444 | 1:3~1:6 | Negative | Online Inquiry |
KO12230 | ZNF444 Knockout cell line (A549) | Human | ZNF444 | 1:3~1:4 | Negative | Online Inquiry |
ZNF444 Gene Knockout Cell Lines represent a pioneering tool in genetic research, designed specifically for the study of the Zinc Finger Protein 444 (ZNF444) gene and its functional roles in various biological processes. These cell lines are created through precise genome editing techniques, such as CRISPR-Cas9, allowing for the targeted deletion of the ZNF444 gene. This knockout model offers researchers an invaluable resource to investigate the gene's contributions to cellular mechanisms, gene regulation, and disease pathology, particularly in contexts such as oncogenesis and developmental biology.
The primary function of ZNF444 is believed to revolve around its role as a transcription regulator, influencing the expression of various downstream target genes involved in critical cellular pathways. By utilizing ZNF444 Gene Knockout Cell Lines, researchers can delineate the gene's regulatory impact, thereby gaining insights into how its loss affects cellular phenotypes, signaling cascades, and overall homeostasis. This deep understanding is crucial for both basic research and translational medicine, providing pathways to identify potential therapeutic targets related to diseases where ZNF444 is implicated.
One of the standout advantages of our ZNF444 knockout cell lines is the accuracy and efficiency of the gene editing technique employed, which minimizes off-target effects commonly associated with other knockout methodologies. Furthermore, our cell lines come with comprehensive validation data, confirming successful gene knockout and the reproducibility of results across different experimental conditions. These features enhance the reliability of data, making it easier for researchers and clinicians to draw conclusions from their experiments.
For researchers focused on gene function ascertainment or therapeutic developments in disease models, our ZNF444 Gene Knockout Cell Lines offer a significant advantage over traditional models. The ability to study the specific effects of ZNF444 in a controlled environment supports the advancement of targeted therapies and deepens our understanding of the genetic underpinnings of diseases.
As a leading provider in the field of precision genetic tools, our company prides itself on delivering high-quality, scientifically validated products that empower researchers and clinicians worldwide. Our expertise ensures that clients receive unparalleled support in utilizing our products to achieve their research and clinical objectives effectively.
Please note that all services are for research use only. Not intended for any clinical use.
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