Gene: ZNF443
Official Full Name: zinc finger protein 443provided by HGNC
Gene Summary: Zinc finger proteins (ZNFs) bind DNA and, through this binding, regulate gene transcription. Most ZNFs contain conserved C2H2 motifs and are classified as Kruppel-type zinc fingers. For a general description of these proteins, see ZNF91 (MIM 603971).[supplied by OMIM, Jul 2002]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32106 | ZNF443 Knockout cell line (HeLa) | Human | ZNF443 | 1:3~1:6 | Negative | Online Inquiry |
KO32107 | ZNF443 Knockout cell line (HCT 116) | Human | ZNF443 | 1:2~1:4 | Negative | Online Inquiry |
KO32108 | ZNF443 Knockout cell line (HEK293) | Human | ZNF443 | 1:3~1:6 | Negative | Online Inquiry |
KO32109 | ZNF443 Knockout cell line (A549) | Human | ZNF443 | 1:3~1:4 | Negative | Online Inquiry |
ZNF443 Gene Knockout Cell Lines are engineered cellular models specifically designed to study the functions and molecular pathways regulated by the ZNF443 gene. This gene, belonging to the zinc finger protein family, has been implicated in various biological processes, including transcriptional regulation and chromatin remodeling. The knockout of ZNF443 allows researchers to investigate the gene's contributions to cellular differentiation, proliferation, and disease states, particularly in cancer and metabolic disorders.
These cell lines utilize precise CRISPR-Cas9 gene editing technology to achieve targeted and efficient gene disruption. By creating a definitive loss-of-function model for ZNF443, researchers can explore alterations in gene expression profiles, signaling cascades, and cellular responses under various conditions. The use of these cell lines in experimental protocols enhances the reliability and validity of findings related to gene function, as it directly isolates the effects of ZNF443 from other confounding variables.
The scientific importance of ZNF443 Gene Knockout Cell Lines extends to their application in drug discovery and therapeutic development. Understanding the role of ZNF443 in pathological contexts could inform targeted therapeutic strategies, while also facilitating the identification of biomarkers for early disease detection. Compared to traditional experimental models, such as siRNA knockdowns, knockout cell lines provide a permanent and stable genetic alteration, which enhances reproducibility across experiments.
For researchers and clinicians seeking to unravel the complexities of gene regulation and its implications in health and disease, ZNF443 Gene Knockout Cell Lines represent a valuable tool. They not only contribute to fundamental biological knowledge but also hold potential for translational applications. Our company specializes in creating high-quality, rigorously validated biological products, ensuring that our researchers have the most reliable models available for their groundbreaking work. With a commitment to excellence and scientific advancement, we empower the research community to push the boundaries of molecular biology and translational medicine.
Please note that all services are for research use only. Not intended for any clinical use.
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