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ZNF189 Knockout Cell Lines

Gene: ZNF189

Official Full Name: zinc finger protein 189provided by HGNC

Gene Summary: Kruppel-like zinc finger proteins such as ZNF189 contain a conserved stretch of 7 amino acids that connects a variable number of DNA-binding zinc finger repeats of the cys(2)his(2) (C2H2) type (summarized by Odeberg et al., 1998 [PubMed 9653648]). Approximately 30% of human Kruppel-like zinc finger proteins contain an N-terminal Kruppel-associated box (KRAB) domain. The KRAB domain consists of approximately 75 amino acids that may be subdivided into an A box, which is present in every KRAB domain and is essential for transcriptional repression, and a B box, which is not always present.[supplied by OMIM, May 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO34545 ZNF189 Knockout cell line (HeLa) Human ZNF189 1:3~1:6 Negative Online Inquiry
KO34546 ZNF189 Knockout cell line (HCT 116) Human ZNF189 1:2~1:4 Negative Online Inquiry
KO34547 ZNF189 Knockout cell line (HEK293) Human ZNF189 1:3~1:6 Negative Online Inquiry
KO34548 ZNF189 Knockout cell line (A549) Human ZNF189 1:3~1:4 Negative Online Inquiry

Background

ZNF189 Gene Knockout Cell Lines represent a cutting-edge tool for molecular biology research, specifically designed to facilitate the investigation of the functional roles of the ZNF189 gene in cellular processes. These engineered cell lines have been generated through precise genome editing techniques, most commonly CRISPR-Cas9, to create targeted deletions or disruptions in the ZNF189 gene. This knockout methodology allows researchers to study the gene's contributions to various biological pathways, including gene regulation, cell differentiation, and response to environmental stressors.

The primary function of ZNF189 is its role as a transcription factor, implicated in regulating gene expression in response to cellular signaling. By utilizing ZNF189 knockout cell lines, researchers can observe phenotypic changes associated with the absence of this gene, thus revealing its impact on cell growth, apoptosis, and other critical biological functions. This functional insight is invaluable for understanding the mechanisms underlying diseases, including certain cancers and developmental disorders, where ZNF189 may play a pivotal role.

In both research and clinical settings, these knockout cell lines serve as powerful tools for drug discovery, toxicity testing, and the development of gene therapies. They provide a robust platform for elucidating the effects of potential therapeutic compounds and understanding the underlying genetics of diseases influenced by ZNF189.

The unique selling points of ZNF189 Gene Knockout Cell Lines include their high specificity and reliability compared to alternative methods of gene suppression, such as RNA interference, which may not achieve complete gene loss. Additionally, these cell lines are readily accessible and compatible with a wide array of assays, from high-throughput screening to detailed molecular analysis, empowering researchers with versatile options for experimental design.

By integrating ZNF189 Gene Knockout Cell Lines into their research, scientists can gain deeper insights into gene function and disease mechanisms, ultimately leading to advancements in therapeutic strategies. Our company excels in providing high-quality biological products, backed by extensive expertise in genetic engineering and cell line development, ensuring you have the dependable tools necessary for pioneering research and innovative clinical solutions.

Please note that all services are for research use only. Not intended for any clinical use.

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