Gene: ZMAT3
Official Full Name: zinc finger matrin-type 3provided by HGNC
Gene Summary: This gene encodes a protein containing three zinc finger domains and a nuclear localization signal. The mRNA and the protein of this gene are upregulated by wildtype p53 and overexpression of this gene inhibits tumor cell growth, suggesting that this gene may have a role in the p53-dependent growth regulatory pathway. Alternative splicing of this gene results in two transcript variants encoding two isoforms differing in only one amino acid. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00155 | ZMAT3 Knockout cell line(HCT 116) | Human | ZMAT3 | 1:2~1:4 | Negative | Online Inquiry |
KO05725 | ZMAT3 Knockout cell line (HeLa) | Human | ZMAT3 | 1:3~1:6 | Negative | Online Inquiry |
KO05726 | ZMAT3 Knockout cell line (HEK293) | Human | ZMAT3 | 1:3~1:6 | Negative | Online Inquiry |
KO05727 | ZMAT3 Knockout cell line (A549) | Human | ZMAT3 | 1:3~1:4 | Negative | Online Inquiry |
ZMAT3 Gene Knockout Cell Lines are specialized cellular models engineered to lack the ZMAT3 gene, which plays a crucial role in various cellular processes, particularly those associated with apoptosis, cell cycle regulation, and genomic stability. By omitting ZMAT3, these cell lines provide researchers with a unique platform to investigate the biological implications of ZMAT3 deficiency, explore its interactions with crucial signaling pathways, and assess the downstream effects on cellular behavior.
The primary function of ZMAT3 Gene Knockout Cell Lines is their ability to facilitate in-depth studies on the role of ZMAT3 in cellular homeostasis and disease progression, particularly in cancer research. The knockout mechanism primarily utilizes CRISPR/Cas9 technology, allowing for precise genetic modifications that enhance the specificity and efficiency of gene editing. This finely-tuned deletion provides a controlled environment for evaluating the importance of ZMAT3 in dendritic cell maturation, apoptosis, and potential roles in tumor suppression.
Scientifically, these cell lines are invaluable for basic and applied research, offering insights that may lead to novel therapeutic strategies targeting ZMAT3-related pathways. Their applications extend to drug screening, gene therapy studies, and investigations into resistance mechanisms in various cancer types, thereby bridging a critical gap between molecular biology and translational medicine.
Compared to existing alternatives, ZMAT3 Gene Knockout Cell Lines stand out due to their genetically verified status and robustness across multiple assays. Unlike transient knockdown methods, these stable lines enable long-term studies without the variability associated with temporary gene silencing. This stability allows for more reliable data collection over extended periods, making them indispensable for thorough experimental designs.
Researchers and clinicians will find immense value in utilizing ZMAT3 Gene Knockout Cell Lines, as they not only advance the understanding of ZMAT3's functionality but also pave the way for innovative therapeutic avenues in oncology and cellular biology. By leveraging these cell lines, users can eliminate guesswork and focus on conclusive results that directly influence research outcomes.
Our company specializes in developing high-quality biological products and tools that empower scientific discovery. With a commitment to advanced methodologies and rigorous testing, we ensure that our offerings, including ZMAT3 Gene Knockout Cell Lines, provide unparalleled support for researchers and clinicians striving to push the boundaries of knowledge in their respective fields.
Please note that all services are for research use only. Not intended for any clinical use.
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