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ZHX1 Knockout Cell Lines

Gene: ZHX1

Official Full Name: zinc fingers and homeoboxes 1provided by HGNC

Gene Summary: The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 1 of this gene family. In addition to forming homodimers, this protein heterodimerizes with members 2 and 3 of the zinc fingers and homeoboxes family. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 8 open reading frame 76 (C8orf76) gene. [provided by RefSeq, Feb 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31035 ZHX1 Knockout cell line (HeLa) Human ZHX1 1:3~1:6 Negative Online Inquiry
KO31036 ZHX1 Knockout cell line (HCT 116) Human ZHX1 1:2~1:4 Negative Online Inquiry
KO31037 ZHX1 Knockout cell line (HEK293) Human ZHX1 1:3~1:6 Negative Online Inquiry
KO31038 ZHX1 Knockout cell line (A549) Human ZHX1 1:3~1:4 Negative Online Inquiry

Background

ZHX1 Gene Knockout Cell Lines are specifically engineered cellular models in which the ZHX1 gene has been systematically disrupted, allowing researchers to study the functional implications of ZHX1 gene loss in various biological contexts. The ZHX1 gene encodes a transcription factor involved in the regulation of gene expression, including critical developmental processes and response pathways in cells. By creating knockout cell lines, scientists can investigate the pathways and mechanisms influenced by ZHX1, providing insights into its role in developmental biology, cancer, and metabolic diseases.

The primary mechanism of these knockout cell lines involves the use of advanced gene-editing techniques, such as CRISPR-Cas9, to create precise deletions or mutations in the ZHX1 gene. This targeted approach enables researchers to observe the resultant phenotypic and molecular changes, facilitating the elucidation of ZHX1's function in cellular processes such as proliferation, differentiation, and stress responses.

ZHX1 Gene Knockout Cell Lines hold significant scientific importance as their use can unlock new avenues of research related to gene regulation and dysregulation in diseases. In clinical settings, understanding the role of ZHX1 could inform therapeutic strategies aimed at diseases where this transcription factor is implicated, thus bridging basic research with clinical applications.

What sets ZHX1 Gene Knockout Cell Lines apart from other models is the combination of specificity and reliability. Unlike broad-spectrum inhibitors or less targeted approaches, these cell lines provide a clean genetic background for studying the implications of ZHX1 loss without confounding variables. This unparalleled specificity enhances experimental reproducibility and allows for more straightforward interpretation of results.

For researchers and clinicians alike, the value of ZHX1 Gene Knockout Cell Lines lies in their ability to yield actionable insights into gene functionality and pathophysiology, making them a crucial tool in modern biological research. By harnessing these knockout models, users can significantly advance their understanding of ZHX1-related pathways and drive forward innovations in disease management.

Our company specializes in providing high-quality biological products, and our expertise in genetic engineering and cell line development ensures that you receive reliable, precise models for your research needs, empowering your scientific endeavors with unparalleled support and resources.

Please note that all services are for research use only. Not intended for any clinical use.

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