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ZFP91 Knockout Cell Lines

Gene: ZFP91

Official Full Name: ZFP91 zinc finger protein, atypical E3 ubiquitin ligaseprovided by HGNC

Gene Summary: The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2. [provided by RefSeq, Oct 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO25871 ZFP91 Knockout cell line (HeLa) Human ZFP91 1:3~1:6 Negative Online Inquiry
KO25872 ZFP91 Knockout cell line (HCT 116) Human ZFP91 1:2~1:4 Negative Online Inquiry
KO25873 ZFP91 Knockout cell line (HEK293) Human ZFP91 1:3~1:6 Negative Online Inquiry
KO25874 ZFP91 Knockout cell line (A549) Human ZFP91 1:3~1:4 Negative Online Inquiry

Background

ZFP91 Gene Knockout Cell Lines are specially engineered cells that lack the expression of the ZFP91 gene, a critical regulator in various cellular processes, including gene transcription and differentiation. These knockout cell lines serve as invaluable tools for elucidating the biological roles of ZFP91, allowing researchers to investigate its contributions to pathophysiological conditions such as cancer and neurodegenerative diseases.

The functionality of ZFP91 Gene Knockout Cell Lines is grounded in the targeted deletion of the ZFP91 gene using precise genetic engineering techniques, such as CRISPR/Cas9 technology. By silencing this gene, researchers can assess the resulting phenotypic changes, cellular signaling pathways, and gene expression profiles, providing insights into ZFP91's role in cellular homeostasis and disease. Moreover, the absence of ZFP91 facilitates the exploration of compensatory mechanisms and interactions with other cellular pathways, making these cell lines a versatile tool in molecular biology and biochemistry studies.

The scientific importance of ZFP91 Gene Knockout Cell Lines extends to applications in both research and clinical settings. They can significantly advance understanding of disease mechanisms and potential therapeutic targets, enabling the development of innovative treatments. Specifically, these knockout lines are crucial for drug screening assays, functional genomics studies, and mechanistic investigations, thereby accelerating the translation of scientific knowledge into clinical practice.

When compared to traditional knockdown approaches, ZFP91 Gene Knockout Cell Lines offer the advantage of a permanent genetic change, providing more stable and reproducible experimental conditions. This stability allows researchers to conduct longitudinal studies with confidence in the consistency of their cell models. Additionally, these knockout lines can easily be manipulated to investigate gene interactions and validate the effects of pharmacological agents.

In conclusion, ZFP91 Gene Knockout Cell Lines represent an essential resource for researchers and clinicians seeking to unravel the complexities of gene function and its implications in health and disease. With a commitment to advancing biological research, our company specializes in providing high-quality, validated gene knockout products, ensuring that scientists have the tools they need to achieve groundbreaking discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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