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ZCCHC8 Knockout Cell Lines

Gene: ZCCHC8

Official Full Name: zinc finger CCHC-type containing 8provided by HGNC

Gene Summary: This gene encodes a scaffold protein which serves as an assessory factor to the nuclear RNA exosome complex. The encoded protein forms a trimeric human nuclear exosome targeting (NEXT) complex, together with hMTR4 and the RNA-binding factor RBM7 which promotes the exosomal degradation of non-coding promoter-upstream transcripts, enhancer RNAs and 3'-extended products of histone- and small nuclear RNA transcription. This complex is also thought to recruit the exosome to degrade intronic RNAs via its interaction with both the exosome and the spliceosome. It contains both an N-terminal zinc-knuckle domain and a C-terminal proline-rich domain. [provided by RefSeq, Apr 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO12447 ZCCHC8 Knockout cell line (HeLa) Human ZCCHC8 1:3~1:6 Negative Online Inquiry
KO12448 ZCCHC8 Knockout cell line (HCT 116) Human ZCCHC8 1:2~1:4 Negative Online Inquiry
KO12449 ZCCHC8 Knockout cell line (A549) Human ZCCHC8 1:3~1:4 Negative Online Inquiry
KO39182 ZCCHC8 Knockout cell line (HEK293) Human ZCCHC8 1:3~1:6 Negative Online Inquiry

Background

ZCCHC8 Gene Knockout Cell Lines are genetically modified cellular systems specifically designed to elucidate the functions and pathways of the ZCCHC8 gene, a critical component implicated in various biological processes, including RNA metabolism and gene regulation. Utilizing CRISPR-Cas9 technology, these cell lines exhibit a targeted deletion of the ZCCHC8 gene, providing a versatile platform for studying its role in cellular mechanisms and pathological conditions.

The primary function of ZCCHC8 Gene Knockout Cell Lines lies in their ability to facilitate research on the absence of the ZCCHC8 gene, enabling scientists to explore its contributions to cellular processes such as proliferation, differentiation, and response to stressors. By comparing the knockout lines with wild-type counterparts, researchers can unravel critical insights into gene function and regulatory networks, ultimately linking molecular changes to phenotypic outcomes.

In both research and clinical settings, these cell lines serve as an invaluable tool for investigating diseases associated with dysregulated RNA metabolism, such as certain cancers and neurodegenerative disorders. They are particularly beneficial for screening potential therapeutic compounds, providing a robust model for evaluating the efficacy of drugs targeting ZCCHC8-related pathways.

What sets ZCCHC8 Gene Knockout Cell Lines apart from alternative models is their high specificity, as they eliminate off-target effects common in earlier gene-editing approaches. Additionally, the scalability and standardization of these cell lines enhance reproducibility in experiments, a vital aspect of scientific rigor.

For researchers and clinicians aiming to decode the complexities of gene function and explore novel therapeutic avenues, ZCCHC8 Gene Knockout Cell Lines represent a cutting-edge solution. With our company’s dedication to advancing genetic research, we offer these cell lines backed by extensive expertise in gene editing and cellular biology, ensuring that our customers benefit from high-quality, scientifically validated products.

Please note that all services are for research use only. Not intended for any clinical use.

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