Gene: YWHAQ
Official Full Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein thetaprovided by HGNC
Gene Summary: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO10108 | YWHAQ Knockout cell line (HeLa) | Human | YWHAQ | 1:3~1:6 | Negative | Online Inquiry |
KO10109 | YWHAQ Knockout cell line (HCT 116) | Human | YWHAQ | 1:2~1:4 | Negative | Online Inquiry |
KO10110 | YWHAQ Knockout cell line (HEK293) | Human | YWHAQ | 1:3~1:6 | Negative | Online Inquiry |
KO10111 | YWHAQ Knockout cell line (A549) | Human | YWHAQ | 1:3~1:4 | Negative | Online Inquiry |
YWHAQ Gene Knockout Cell Lines are genetically engineered cellular models specifically designed to study the function of the YWHAQ gene, which encodes a member of the 14-3-3 protein family known for its role in cellular signaling, proliferation, and apoptosis. These cell lines feature a complete knockout of the YWHAQ gene, eliminating its expression and allowing researchers to investigate the downstream effects of this absence on various cellular pathways and biological processes.
The primary function of the YWHAQ Gene Knockout Cell Lines is to enable detailed functional analyses of the YWHAQ protein's involvement in signal transduction and its interactions with other cellular proteins. The knockout mechanism is achieved through CRISPR/Cas9 technology, providing a precise, targeted disruption of the gene, which allows for thorough studies of resultant phenotypic changes. These cellular models are invaluable for elucidating the role of YWHAQ in diseases such as cancer, neurodegenerative disorders, and metabolic syndromes, where aberrations in signaling pathways often occur.
The scientific importance of these cell lines is vast, providing an essential tool for researchers engaged in basic and translational research. They can be used in drug discovery, target validation, and biomarker studies, making them indispensable in various clinical applications. Compared to traditional cell lines, the YWHAQ Gene Knockout Cell Lines exhibit enhanced relevance to human conditions, facilitating more translationally applicable findings.
Unique advantages of the YWHAQ Gene Knockout Cell Lines include their specificity and robustness, offering researchers consistent results and reducing variability typically seen in other models. Furthermore, their production adheres to rigorous quality control standards, ensuring that they meet the expectations of both academic and industrial laboratories.
In summary, the YWHAQ Gene Knockout Cell Lines represent a cutting-edge resource for researchers and clinicians focused on understanding the intricate roles of the YWHAQ protein. Our company specializes in the development of high-quality and innovative biological products, ensuring rigorous scientific standards and providing exceptional support to empower your research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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