Gene: YWHAG
Official Full Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gammaprovided by HGNC
Gene Summary: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08489 | YWHAG Knockout cell line (HeLa) | Human | YWHAG | 1:3~1:6 | Negative | Online Inquiry |
KO08490 | YWHAG Knockout cell line (HCT 116) | Human | YWHAG | 1:2~1:4 | Negative | Online Inquiry |
KO08491 | YWHAG Knockout cell line (HEK293) | Human | YWHAG | 1:3~1:6 | Negative | Online Inquiry |
KO08492 | YWHAG Knockout cell line (A549) | Human | YWHAG | 1:3~1:4 | Negative | Online Inquiry |
YWHAG Gene Knockout Cell Lines are genetically modified cell lines engineered to lack the expression of the YWHAG gene, which encodes the 14-3-3 gamma protein involved in several essential intracellular processes, including signal transduction and regulation of cellular growth. These knockout cell lines serve as powerful tools in molecular biology, enabling researchers to investigate the functional role of YWHAG and its impact on various biological pathways.
The key mechanism by which YWHAG gene knockout cell lines operate is through the disruption of the gene's coding sequence, leading to a complete absence of 14-3-3 gamma protein. This allows for the dissection of signaling pathways where YWHAG plays a crucial role, facilitating studies on cellular processes such as apoptosis, cell cycle regulation, and stress response mechanisms. Researchers can observe the physiological and biochemical changes that occur in the absence of YWHAG, thereby elucidating its contributions to cellular behavior and disease pathogenesis.
The scientific importance of these cell lines is profound, particularly in cancer research, neurobiology, and studies of metabolic disorders. By utilizing YWHAG knockout cell lines, scientists can explore how the absence of this regulatory protein influences tumor growth, neuronal function, or metabolic pathways. The insights gained can lead to fundamental discoveries and potential therapeutic targets.
One significant advantage of YWHAG Gene Knockout Cell Lines is their precision in modeling specific conditions compared to alternative methods such as transient knockdown approaches, which may not provide stable and consistent results. Furthermore, these cell lines are meticulously validated for specificity and functionality, ensuring that researchers are working with reliable models that enhance the reproducibility of experiments.
This product is invaluable for both academic and pharmaceutical researchers seeking to understand complex cellular mechanisms at a deeper level. By providing a clear avenue to probe the interplay of YWHAG in various biological processes, these cell lines represent a critical asset in advancing our understanding of health and disease.
Our company specializes in the development of innovative biological tools designed to empower researchers in their scientific pursuits. Our commitment to quality and excellence is reflected in our extensive portfolio of gene knockout cell lines, which are meticulously characterized to support groundbreaking research.
Please note that all services are for research use only. Not intended for any clinical use.
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