Home / WHAMM Knockout Cell Lines

WHAMM Knockout Cell Lines

Gene: WHAMM

Official Full Name: WASP homolog associated with actin, golgi membranes and microtubulesprovided by HGNC

Gene Summary: This gene encodes a protein that plays a role in actin nucleation, Golgi membrane association and microtubule binding. The encoded protein is a nucleation-promoting factor that regulates the Actin-related protein 2/3 complex. The activated complex initiates growth of new actin filaments by binding to existing actin filaments. The encoded protein also functions in regulation of transport from the endoplasmic reticulum to the Golgi complex and in maintenance of the Golgi complex near the centrosome. Four pseudogenes of this gene are present on the same arm of chromosome 15 as this gene. [provided by RefSeq, Aug 2013]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO28794 WHAMM Knockout cell line (HeLa) Human WHAMM 1:3~1:6 Negative Online Inquiry
KO28795 WHAMM Knockout cell line (HCT 116) Human WHAMM 1:2~1:4 Negative Online Inquiry
KO28796 WHAMM Knockout cell line (HEK293) Human WHAMM 1:3~1:6 Negative Online Inquiry
KO28797 WHAMM Knockout cell line (A549) Human WHAMM 1:3~1:4 Negative Online Inquiry

Background

WHAMM Gene Knockout Cell Lines are sophisticated cellular models engineered to facilitate the functional analysis of the WHAMM gene, pivotal in cellular processes such as endosomal trafficking and actin dynamics. These specially designed cell lines utilize CRISPR-Cas9 technology to achieve targeted disruption of the WHAMM gene, enabling researchers to study its role in various biological pathways and its implications in disease states.

The primary mechanism through which these knockout cell lines function involves the induction of frame-shifting mutations within the WHAMM gene, leading to a loss of protein expression. This allows researchers to observe the phenotypic consequences of WHAMM gene absence, thereby unraveling its contributions to cellular architecture, vesicle transport, and potentially oncogenic pathways. The clarity offered by these models is indispensable for understanding the intricate relationships between gene function and cellular behavior.

In the realm of scientific research and clinical applications, WHAMM Gene Knockout Cell Lines serve as vital tools for drug development, gene therapy exploration, and the elucidation of molecular mechanisms underlying various diseases, including neurodegenerative disorders and cancers. Their use in high-throughput screening environments empowers scientists to rapidly assess the impact of compounds on cellular systems devoid of the WHAMM protein, enhancing the efficiency of drug discovery efforts.

What sets WHAMM Gene Knockout Cell Lines apart from conventional knockout models is their precise gene editing capability, high reproducibility, and adaptability to various experimental conditions. This specificity minimizes off-target effects and provides researchers with reliable data, lessening the need for extensive validation that often accompanies alternative methods.

For researchers and clinicians dedicated to advancing knowledge in cellular and molecular biology, the value of these knockout cell lines lies in their potential to accelerate discoveries and foster innovations in therapeutic strategies. Our company prides itself on offering high-quality biological products backed by extensive expertise in gene editing technology, ensuring researchers have access to the most reliable tools for their groundbreaking studies.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.