Gene: WFDC3
Official Full Name: WAP four-disulfide core domain 3provided by HGNC
Gene Summary: This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. The encoded protein contains four WFDC domains. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Alternatively spliced transcript variants have been observed but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO09567 | WFDC3 Knockout cell line (HCT 116) | Human | WFDC3 | 1:2~1:4 | Negative | Online Inquiry |
WFDC3 Gene Knockout Cell Lines are engineered cell models specifically designed to study the role of the WFDC3 gene, which encodes a protein implicated in various biological processes, including immune regulation and cellular signaling. These knockout cell lines are created using CRISPR/Cas9 technology, resulting in precise deletions that enable researchers to investigate the gene's functional contribution in both physiological and pathological contexts.
The primary function of WFDC3 Gene Knockout Cell Lines is to provide a controlled environment to observe the phenotypic and molecular consequences of the absence of the WFDC3 protein. The mechanistic insights gained from these models can facilitate a better understanding of cell differentiation, immune response, and potential dysregulations in diseases such as autoimmunity and cancer. Researchers can utilize these cell lines for high-throughput screening, pathway analysis, and assessing the effects of drug interventions, making them invaluable in both basic and translational research settings.
The scientific importance of WFDC3 Gene Knockout Cell Lines lies in their ability to uncover novel insights into gene function and interactions in live cells, providing a powerful platform to validate findings from in silico models and establish biological relevance. Compared to conventional methods, such as RNA interference, these knockout models offer a permanent, stable alteration of gene expression, leading to more robust experimental results.
One of the unique selling points of our WFDC3 Gene Knockout Cell Lines is the specificity and efficiency of the CRISPR technology used in their creation, which minimizes off-target effects and enhances the fidelity of experimental outcomes. Additionally, these cell lines can be paired with complementary technologies, such as single-cell RNA sequencing, to further delve into gene regulatory networks and cellular heterogeneity.
In conclusion, WFDC3 Gene Knockout Cell Lines are a crucial resource for researchers and clinicians aiming to explore the nuances of gene function and disease mechanisms. Our commitment to quality and innovation, underscored by our team's extensive expertise in molecular biology and genetic engineering, ensures that our products stand at the cutting edge of biological research and offer unparalleled support for advancing scientific discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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